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Prednisolone is a glucocorticoid with the general properties of the corticosteroids. It is used as anti-inflammatory or immunosuppressive agent in asthmatic condition mostly in pediatric and geriatric population. So the present investigation was conducted with an aim of to formulate a taste masked patient friendly dosage form. i.e. mouth dissolving tablets of prednisolone. In this study, taste masking of drug was critical parameter for this study. Masking of bitter taste of prednisolone was carried out using techniques like preparation of solid dispersion with PEG 6000, complex formation with Indion-204 resin and beta-cyclodextrin. Among them complex prepared from beta-cyclodextrin in weight ratio 1:4 was optimized basis on taste panel evaluation and drug release from complex. A successful taste masking of complex was confirmed by time intensity method and also by taking drug release in simulated gastric fluid and in simulated salivary fluid.
Über den Autor / die Autorin
Mr. Basu is working as an Asst. Prof. in Atmiya Institute of Pharmacy, Rajkot, Gujarat, India. M.Pharm from Bapuji Pharmacy College, affiliated to Rajiv Gandhi University of Health Sciences, Bangalore & persuing PhD. He has more than 4 yrs teaching & 2yrs research experience, guided 8 M.Pharm students, published 16 papers, & attended 9 conference.
