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Thisvolume details our current understanding of the architecture and signalingcapabilities of the B cell antigen receptor (BCR) in health and disease. Thefirst chapters review new insights into the assembly of BCR components andtheir organization on the cell surface. Subsequent contributions focus on themolecular interactions that connect the BCR with major intracellular signalingpathways such as Ca2+ mobilization, membrane phospholipidmetabolism, nuclear translocation of NF-kB orthe activation of Bruton's Tyrosine Kinase and MAP kinases. These elementsorchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamicsfor antigen internalization. Furthermore, a key mechanism of how B cellsremember their cognate antigen is discussed in detail. Altogether, the discoveriespresented provide a better understanding of B cell biology and help to explainsome B cell-mediated pathogenicities, like autoimmune phenomena or theformation of B cell tumors, whilealso paving the way for eventually combating thesediseases.
Inhaltsverzeichnis
Assembly and function of the precursor B-cell receptor.- Receptor Dissociation and B cell activation.- Molecular mechanisms of B cell antigen gathering and endocytosis.- BTK signaling in B cell differentiation and autoimmunity.- The memory function of the B cell antigen receptor.- PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL).- Role of Calcium Signaling in B Cell Activation and Biolog.- Roles of the NF-kappaB pathway in B-lymphocyte biology.- MAP kinase cascades in antigen receptor signaling and physiology.
Über den Autor / die Autorin
Tomohiro Kurosaki, MD, PhD, is a professor at WPI Immunology Frontier Research Center at Osaka University, Japan
Jürgen Wienands, PhD, is a professor of Cellular and Molecular Immunology at the University of Göttingen, Germany
Zusammenfassung
This
volume details our current understanding of the architecture and signaling
capabilities of the B cell antigen receptor (BCR) in health and disease. The
first chapters review new insights into the assembly of BCR components and
their organization on the cell surface. Subsequent contributions focus on the
molecular interactions that connect the BCR with major intracellular signaling
pathways such as Ca
2+
mobilization, membrane phospholipid
metabolism, nuclear translocation of NF-kB or
the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements
orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics
for antigen internalization. Furthermore, a key mechanism of how B cells
remember their cognate antigen is discussed in detail. Altogether, the discoveries
presented provide a better understanding of B cell biology and help to explain
some B cell-mediated pathogenicities, like autoimmune phenomena or the
formation of B cell tumors, whilealso paving the way for eventually combating these
diseases.
