Molecular Biology of Cancer - Mechanisms, Targets, and Therapeutics - 4th edition

Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.Using the hallmarks of cancer as a starting point, the book looks at the cellular and molecular mechanisms underpinning the transformation of cells into cancer cells. After discussing the theory, each chapter then demonstrates how this knowledge can be directly applied to the development of new targeted therapies, giving the reader a clear appreciation of how the theory translates to tackling the disease.Drawing on the latest research in this dynamic field, the author makes cutting edge science readily accessible. The book features a variety of learning features - 'Pause and think', 'How do we know that?', self-tests and activities - to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the subject to the point of overwhelming with detail, but on acquiring a solid understanding of the essentials and an appreciation of how a theoreticalunderstanding can be transformed into therapeutic benefit.Online Resource CentreThe Online Resource Centre features:For registered adopters of the book:- Figures from the book, ready to download.- A test bank of multiple choice questions, with feedback linked to the book.For students:- Web links to a range of additional cancer biology resources on the internet.

Inhaltsverzeichnis

1 Introduction; 2 DNA structure and stability: mutations versus repair; 3 Regulation of gene expression; 4 Growth factor signaling and oncogenes; 5 The cell cycle; 6 Growth inhibition and tumor suppressor genes; 7 Apoptosis; 8 Stem cells and consequences of blocked differentiation; 9 Metastasis; 10 Angiogenesis; 11 Nutrients, hormones, and gene interactions; 12 Tumour immunology and immunotherapy; 13 Infectious agents and inflammation; 14 New technologies and drug development

Über den Autor / die Autorin

Dr Lauren Pecorino obtained her PhD in Cell and Developmental Biology at the State University of New York at Stony Brook, USA. She then moved to London to carry out a post-doctoral tenure at the Ludwig Institute for Cancer Research where she studied the phenomenon of limb regeneration. Here she used a technique called biolistics, using a 'gene gun' to shoot gold bullets coated with DNA to introduce genes into the regenerating limbs of live newts. Since 1996, Lauren has been a member of academic staff at the University of Greenwich, where she developed her interest in teaching Cancer Biology.

Zusammenfassung

Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.

Using the hallmarks of cancer as a starting point, the book looks at the cellular and molecular mechanisms underpinning the transformation of cells into cancer cells. After discussing the theory, each chapter then demonstrates how this knowledge can be directly applied to the development of new targeted therapies, giving the reader a clear appreciation of how the theory translates to tackling the disease.

Drawing on the latest research in this dynamic field, the author makes cutting edge science readily accessible. The book features a variety of learning features - 'Pause and think', 'How do we know that?', self-tests and activities - to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the subject to the point of overwhelming with detail, but on acquiring a solid understanding of the essentials and an appreciation of how a theoretical
understanding can be transformed into therapeutic benefit.

Online Resource Centre

The Online Resource Centre features:

For registered adopters of the book:
- Figures from the book, ready to download.
- A test bank of multiple choice questions, with feedback linked to the book.

For students:
- Web links to a range of additional cancer biology resources on the internet.

Zusatztext

Review of previous edition: Dr. Pecorino has done a fantastic job... The book's engaging writing-style and well thought out structure welcomes anyone with an interest in studying cancer in thorough, interesting detail. Reading this text was a pleasure, benefited me greatly educationally and made me feel like being a real part of the teaching - as though things were being explained to me in a one-on-one tutorial, an experience that most other medical
textbooks don't provide!

Bericht

Dr Pecorino's monumental achievement highlights the most up-to-date and exciting discoveries ongoing in the molecular studies of cancer. Professor David Lyden, Weill Cornell Medical College, Cornell University

Produktdetails

• Autoren: Lauren Pecorino, Lauren (Principal Lecturer in Cancer Bio Pecorino, Lauren (Principal Lecturer in Cancer Biology Pecorino
• Verlag: Oxford University Press
• Sprache: Englisch
• Produktform: Taschenbuch
• Erschienen: 02.06.2016
• EAN: 9780198717348
• ISBN: 978-0-19-871734-8
• Seiten: 400
• Themen: Naturwissenschaften, Medizin, Informatik, Technik; Biochemie, Chirurgie, Molekularbiologie, Zellbiologie (Zytologie), Biosciences