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Informationen zum Autor Professor Jean-François Dufour , MD, PhD, Chief, Department of Clinical Pharmacology, University Clinic Visceral Surgery and Medicine, Bern, Switzerland. Professor Dufour is on the governing board of the European Association for the Study of the Liver (EASL). He also serves as Associate Editor for the Wiley journal Liver International and is on the editorial board for the following journals: Journal of Hepatology; Clinical Science; World Journal of Gastroenterology Professor Pierre-Alain Clavien , MD, PhD, FACS, FRCS (Eng), FRCS (Ed), Professor and Chairman, Department of Surgery. Head, Division of Visceral & Transplantation Surgery, University Hospital Zurich, Switzerland. Professor Clavien is a world-wide renowned surgeon-scientist, currently professor and chairman of the Department of Surgery in Zurich, Switzerland. His areas of research include organ preservation, liver ischemia-reperfusion injury and regeneration, and pathogenesis of cancer, as well as outcome research. He received many competitive grants and awards, including one of the most prestigious prices for scientific research, the Otto Naegeli Award. Klappentext Signalling Pathways in Liver Diseases 3E again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signalling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format.With increased focus on the comprehension of cellular mechanisms involved in steatohatitis, cirrhosis and liver tumours, which has led in changes to the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as:* Autophagy* Notch Pathway* PI3K/PTEN Signaling in Liver Diseases* Sirtuins* Hepcidin and Iron* Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis* Oxidative Stress and Signaling in the LiverProfessors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom will provide write a clear yet comprehensive review of their chosen topic. Chapters will contain clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge.Signalling Pathways in Liver Diseases 3E is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist. Zusammenfassung Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. Inhaltsverzeichnis List of Contributors, vii 1 Hepatocytes 1 Jean-François Dufour and Joachim C. Mertens 2 Signaling pathways in biliary epithelial cells 15 M. Fatima Leite, Mateus T. Guerra, Viviane A. Andrade and Michael H. Nathanson 3 Stellate cells 34 Alessandra Caligiuri and Fabio Marra 4 Kupffer cells 61 Amirali Kiyani and Ekihiro Seki 5 Hepatic sinusoidal endothelial cells 73 Moira B. Hilscher Robert C. Huebert and Vijay H. Shah 6 Extracellular matrix 85 Scott L. Friedman 7 Platelets: a new cell type in liver physiology 97 Mickaël Lesurtel and Pierre?]Alai...
