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Arylierungen gehören zu den wichtigsten Reaktionen der modernen Synthesechemie. Lutz Ackermann konnte ein internationales Team renommierter Fachleute dafür begeistern, Beiträge für ein erstes Werk ausschließlich zu diesem Thema zu verfassen. Von einem historischen Überblick ausgehend, behandelt das Buch die "heißesten" Forschungsfelder - unter anderem die palladiumkatalysierte Arylierung von N-H- und alpha-C-H-aciden Bindungen, die kupferkatalysierte Arylierung der N-H- und der O-H-Bindung sowie Arylierungsreaktionen von Alkenen und Alkinen. Interessant auch für die Chemie- und Pharmazieindustrie!
Inhaltsverzeichnis
ARYLATION REACTIONS: A HISTORICAL PERSPECTIVEStructure and Bonding of BenzeneSyntheses of Substituted (Hetero)Arenes, and the Contents of this BookMETAL-CATALYZED COUPLING REACTIONS WITH ARYL CHLORIDES, TOSYLATES AND FLUORIDESIntroductionCoupling Reactions of Aryl ChloridesCoupling Reactions Aryl FluoridesCoupling Reactions of Aryl TosylatesPALLADIUM-CATALYZED ARYLATIONS OF AMINES AND ALPHA-C-H ACIDIC COMPOUNDSIntroductionPalladium-Catalyzed Arylations of AminesPalladium-Catalyzed Arylations of Alpha-C-H Acidic CompoundsCOPPER-CATALYZED ARYLATIONS OF AMINES AND ALCOHOLS WITH BORON-BASED ARYLATING REAGENTSIntroductionDiscovery and Development of a New O-H Bond Arylation Reaction: From Stoichiometric to Catalytic in CopperMechanistic ConsiderationsMiscellaneous ApplicationsDevelopment of a New N-H Bond Arylation ReactionDevelopment of a New N-H Bond Arylation Reaction: Catalytic in CopperMETAL-CATALYZED ARYLATIONS OF NONACTIVATED ALKYL (PSEUDO)HALIDES VIA CROSS-COUPLING REACTIONSIntroductionPalladium-Catalyzed Arylations of Alkyl (Pseudo)HalidesNickel-Catalyzed Arylations of Alkyl (Pseudo)HalidesIron-Catalyzed Arylations of Alkyl (Pseudo)HalidesCopper- and Cobalt-Catalyzed Arylations of Alkyl (Pseudo)HalidesARYLATION REACTIONS OF ALKYNES: THE SONOGASHIRA REACTIONIntroductionPalladium-Catalyzed Reactions: Ligands and Reaction ProtocolsAlternative Metal CatalystsMechanism of the Sonogashira ReactionPALLADIUM-CATALYZED ARYLATION REACTIONS OF ALKENES (MIZOROKI-HECK REACTION AND RELATED PROCESSES)IntroductionMizoroki-Heck ArylationsReductive Mizoroki-Heck-Type ArylationsOxidative Mizoroki-Heck-Type ArylationsMODERN ARYLATIONS OF CARBONYL COMPOUNDSIntroductionEnantioselective Arylation of AldehydesEnantioselective Arylation of KetonesEnantioselective Arylation of IminesConjugate Asymmetric ArylationTandem ProcessesEnantioselective Friedel-Crafts ArylationMETAL-CATALYZED DIRECT ARYLATIONS (EXCLUDING PALLADIUM)IntroductionRhodium-Catalyzed Direct ArylationsRuthenium-Catalyzed Direct ArylationsIridium-, Copper- and Iron-Catalyzed Direct ArylationsPALLADIUM-CATALYZED DIRECT ARYLATION REACTIONSIntroductionIntermolecular Arylation of Functionalized ArenesIntramolecular Reaction of Haloaryl-Linked ArenesIntermolecular Arylation Reactions of Heteroaromatic CompoundsMECHANISTIC ASPECTS OF TRANSITION METAL-CATALYZED DIRECT ARYLATION REACTIONSIntroductionPalladium-Catalyzed Intramolecular Direct ArylationIntermolecular Metal-Catalyzed Direct Arylation of ArenesMetal-Catalyzed Heteroaryl-Aryl and Heteroaryl-Heteroaryl Bond FormationDirect Arylation via MetallacyclesCross-Dehydrogenative CouplingsARYLATION REACTIONS INVOLVING THE FORMATION OF ARYNESIntroductionGeneration of ArynesElectrophilic Coupling of ArynesPericyclic Reactions of ArynesTransition Metal-Catalyzed Reactions ArynesRADICAL-BASED ARYLATION METHODSIntroductionSRN1-Type Radical ArylationsHomolytic Aromatic SubstitutionsArylations Using Aryl RadicalsPHOTOCHEMICAL ARYLATION REACTIONSIntroductionPhotochemical Formation of Aryl-C BondsPhotochemical Formation of Aryl-N Bonds
Über den Autor / die Autorin
Lutz Ackermann obtained his Ph.D. in the group of Alois Fürstner at the Max-Plank-Institut für Kohlenforschung in Mülheim, Germany. After a postdoctoral stay with Robert G. Bergman at the University of California at Berkeley, USA, he initiated his independent career at the Ludwig-Maximilians-University Munich. His recent awards include an Emmy Noether `Junior Research Group from the DFG, a DuPont Center for Collaborative Research&Education Grant, a Thieme journal-award, and an ORCHEM-Price from the GDCh.
Zusammenfassung
Arylierungen gehören zu den wichtigsten Reaktionen der modernen Synthesechemie. Lutz Ackermann konnte ein internationales Team renommierter Fachleute dafür begeistern, Beiträge für ein erstes Werk ausschließlich zu diesem Thema zu verfassen. Von einem historischen Überblick ausgehend, behandelt das Buch die "heißesten" Forschungsfelder - unter anderem die palladiumkatalysierte Arylierung von N-H- und alpha-C-H-aciden Bindungen, die kupferkatalysierte Arylierung der N-H- und der O-H-Bindung sowie Arylierungsreaktionen von Alkenen und Alkinen. Interessant auch für die Chemie- und Pharmazieindustrie!
