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With the decade-long desire for optimum performance using biomaterials without additional surgery, replacement or maintenance, a desperate search is underway for tailoring the physical and physico-chemical properties of the materials surface and the biosystem.This is the first book to concentrate on the highly important area of metal-based implants and their improved functionality and acceptance by the body. It thus focuses on the properties of biomaterial-tissue interfaces, which are discussed in terms of the biomaterials and the specific biological environments they are used in. Strong emphasis is placed on the recent results and success in improving the interface characterization towards implant refinement.From the contents:I. Interface Influence of Materials and Surface Modifications Passivity-inducing and -retaining Surfaces Topological Surface Modifications Chemical Surface ModificationsII. Physical and Physicochemical Surface Characterization Surface Topology Electrochemical Characterization Spectroscopic Interface Characterization Physical Characterization of Protein AdsorptionIII. Biological Characterization of the Interface and Materials Related Biosystem Reactions Protein and Cell Adhesion Mechanisms Material-induced Cell Interactions Topology-dependent Cellular Interactions Materials-dependent Formation of New Hard Tissue
Inhaltsverzeichnis
I. Interface Influence of Materials and Surface ModificationsIntroductionMetals and AlloysTopological Surface ModificationsChemical Surface ModificationsII. Physical and Physicochemical Surface CharacterizationIntroductionSurface TopologySpectroscopic Interface CharacterizationPhysical Characterization of Protein AdsorptionComputer Simulations: Modeling of Protein Adsorption on Nanostructured Metallic SurfacesIII. Biological Characterization of the Interface and Materials Related Biosystem ReactionsProtein and Cell Adhesion MechanismsMaterial-induced Cell InteractionsTopology-dependent Cellular InteractionsMaterials-dependent Formation of New Hard Tissue
Über den Autor / die Autorin
Jürgen Breme was the department head of Metallic Materials at the University of Saarland in Saarbrücken, Germany, until his retirement in October 2005. Having obtained his academic degrees from RWTH Aachen and University of Erlangen, he moved to Saarbrücken in 1988. He has authored over 200 scientific publications, including several books. His principal research interests are in the fields of titanium, titanium alloys and metallic biomaterials including composites, e.g. preparation and characterization of functional ceramic layers on implant materials.
James Kirkpatrick holds the Chair in Pathology at the Johannes Gutenberg University in Mainz, Germany, and has three doctorate degrees from the Queen's University of Belfast, Ireland. he is a Fellow of the Royal College of Pathogists in London and Honorary Professor of two universities in China. He has worked at the universities in Ulm, Manchester and Aachen, is author of over 250 peer-reviewed articles and more than 700 scientific presentations. He is currently President of the European Society for Biomaterials and Associate Editor of Biomaterials and the Journal of Pathology.
Roger Thull is physicist and Chair of Functional Medical and Dental Materials at Würzburg University, Germany. Before this, he spent 15 years in the Department of Medical Engineering of the University of Erlangen/ Nuremberg with R&D in different biomaterials engineering fields. His interdisciplinary work focuses on the science and research of biomaterials, design of sceletal implants, and testing of materials and medical devices. Since 1990 surface modifications (PVD, Sol-Gel) are being developed at the department as for polymer and metallic implants in the cardio-vascular, dental, and orthopaedic fields.
Zusammenfassung
Clearly divided into three sections on the interface influence of materials and surface modifications, the physical and physicochemical surface characterization, and the biological characterization of the interface and biosystem reactions, this book is the first to concentrate on the highly important area of metal-based implants and their improved functionality and acceptance by the body.
