Biochemistry of Pulmonary Emphysema

Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for reestablishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy.

Inhaltsverzeichnis

From the Contents: Pulmonary Emphysema: What's going on.- Elastin and the Lung.- An Introduction to the Endopeptidases.- Lung Proteinase and Emphysema.- Multiple Functions of Neutrophil Proteinases and their Inhibitor Complexes.- Kinetics of the Interaction of Human Leucocyte Elastase with Protein Substrates.- Proteinase Inhibitor Candidates for Therapy of Enzyme-Inhibitor Imbalances.- Antileucoprotease (Secretory Leucocyte Proteinase Inhibitor), A Major Proteinase Inhibitor in the Human Lung.- Development and Evaluation of Antiproteases as Drugs for Preventing Emphysema.- Genetic Control of Human Alpha-1-Antitrypson and Hepatic Gene Therapy.- Neutrophils, Neutrophil Elastase and the Fragile Lung.

Produktdetails

• Mitarbeit: L. Casali (Herausgeber), L Casali et al (Herausgeber), C. Grassi (Herausgeber), M. Luisetti (Herausgeber), Travis (Herausgeber), J Travis (Herausgeber), J. Travis (Herausgeber)
• Verlag: Springer, Berlin
• Sprache: Englisch
• Produktform: Taschenbuch
• Erschienen: 08.05.2014
• EAN: 9781447137733
• ISBN: 978-1-4471-3773-3
• Seiten: 200
• Gewicht: 387 g
• Illustration: XV, 200 p. 13 illus.
• Serien: Current Topics in Rehabilitation; Current Topics in Rehabilitation
• Themen: Geisteswissenschaften, Kunst, Musik > Psychologie > Angewandte Psychologie; Naturwissenschaften, Medizin, Informatik, Technik > Medizin > Medizinische Fachberufe; Sachbuch > Psychologie, Esoterik, Spiritualität, Anthroposophie > Angewandte Psychologie