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This book covers a hot subject in cell biology; i.e. how the cell environment sends messages to the cell, regulates gene expression, and modulates the cell phenotype. For a long time the extracellular matrix was believed to have only a supporting role for cell attachment. However, it became apparent that the matrix participates actively in cell metabolism. The experiments that led to this conclusion are described in this volume. Progressively, molecules have been identified that transmit this signaling at the cell-matrix interface. Their identity and mechanism of action are also illustrated in this book. Finally, it explains the role the cell-matrix relationship plays in the regulation of cell proliferation, cell differentiation, and the expression of malignancy.
Inhaltsverzeichnis
- Topological Constraints Carry Signaling from the Cell Matrix to the Genome
- The Transmission of Contractility Through Cell Adhesion
- Role of Focal Adhesion Kinase in Signaling by the Extracellular Matrix
- Interactions Between Cells and Extracellular Matrix. Signaling by Integrins and the Elastin-Laminin Receptor
- Regulation of Gene Expression by Changes in Cell Adhesion
- Expression of Liver-Specific Genes in Hepatocytes Cultured in Collagen Cell Matrix
- Collagen Type I: a Substrate and a Signal for Invasion
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