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Informationen zum Autor Irving M. Reti is an Associate Professor and Director of The Brain Stimulation Program at The Johns Hopkins Hospital, USA. Klappentext Brain stimulation technologies are both tools to probe brain function and to provide therapeutic options for patients with neuropsychiatric disease where pharmacological options are not viable. Although the field has been in existence for over seventy years, research interest in brain stimulation has been on the rise particularly in the last two decades.Brain Stimulation: Methodologies and Interventions is an introduction to the field of brain stimulation technology and its applications. The book explores how brainstimulating technologies work in the context of brain pathways that mediate normal and abnormal brain function. Chapters cover neuroanatomy and activity dependent changes in neuronal function triggered by brain stimulation, as well as applications of brain stimulation technologies themselves, including noninvasive procedures that rely on convulsive or seizure therapeutics, and non-convulsive therapies such as magnetic and electrical brain stimulation.Authored by an international group of leaders in the field, Brain Stimulation is a valuable resource for both neuroscience researchers and clinicians. Zusammenfassung Brain stimulation technologies are both tools to probe brain function and to provide therapeutic options for patients with neuropsychiatric disease where pharmacological options are not viable. Inhaltsverzeichnis Contributors xi 1 Introduction to Brain Stimulation 1 Irving M. Reti and Andrew D. Chang Introduction 1 A Historical Perspective 2 Focal Activation 3 Connectivity 5 Development of Invasive Brain Stimulation 7 Ethical Issues 9 References 9 PART A BRAIN CIRCUITRY AND PLASTICITY 13 2 A Balanced Mind: A Network Perspective on Mood and Motivation Brain Pathways 15 Morten L. Kringelbach Introduction 15 Dysregulation of Emotion and Mood 18 Potential for Intervention 21 Conclusion 23 References 24 3 Motor Pathways, Basal Ganglia Physiology, and Pathophysiology 29 Hagai Bergman, Shiran Katabi, Maya Slovik, Marc Deffains, David Arkadir, Zvi Israel, and Renana Eitan Introduction 29 The Classic Models of Basal Ganglia Anatomy 30 Basal Ganglia Physiology 33 The Pathophysiology of Hypo- and HyperDopaminergic States 35 From Physiology to Understanding and Therapy-the Computational Models of the Basal Ganglia 37 References 41 4 Viewing Brain Stimulation from a Plasticity Perspective 45 Jay M. Baraban Long-Term Potentiation: A Primer 45 AMPA Versus NMDA Receptors 46 Distinct Mechanisms of LTP Induction and Expression 48 Synapse Specificity of LTP 48 Relevance of LTP Mechanisms to Mode of Action of tDCS 49 Long-Term Depression 51 Metaplasticity and Monoamines 52 Clues to rTMS Mode of Action 52 Future Directions 54 Summary 55 References 55 PART B TECHNOLOGY 57 (1) Non-Invasive Brain Stimulation Modalities 59 (a) Convulsive 59 5 Introduction to Convulsive Therapy 61 Richard D. Weiner Introduction 61 The History of Convulsive Therapy 62 Electroconvulsive Therapy: Basic Principles 64 Electroconvulsive Therapy: Clinical Role 67 Magnetic Seizure Therapy (MST) 76 Focal Electrically Administered Seizure Therapy (FEAST) 77 Future of Convulsive Therapy 77 References 78 6 Improving ECT Efficacy and Decreasing Cognitive Side Effects 83 Keith G. Rasmussen Introduction 83 ECT Outcome Assessment: Therapeutic Efficacy and Cognitive Side Effects 83 ECT Treatment Techn...
