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J. G. MCVIE The impact of therapy on one subset of lung cancer, the "small cell" type has been significant and lasting. The reality of cure for even a fraction of patients with this disease has caused reverberations in the pathology lab where the responsibili. '~y and challenge of diagnosis of this vital sub group lies. No less dramatic has been the discovery that the cell types of lung cancer have recognisable growth characteristics in serum free culture, they are recognisable by patterns of markers and some produce growth factors which autoregulate their eventual fate. Many of the discoveries from the biological studies have impacted on the pathologist in the form of disturbing evidence for a single stem cell origin for all the cell types of lung cancer and in the shape of new facilitation in diagnosis by appli cation of immunoperoxidase techniques. Monoclonal antibodies raised against oncogene products, growth factor receptor sites, "bystander" cell membrane proteins can all be applied to cytology specimens and frozen or paraffin fixed tissue sections to aid diagnosis and some can be used in sequential serum assay to monitor therapy and predict prognosis. Adding to these extraordinary tools, the sophistication of electron micro scopy and immuno-electrcn microscopy, new techniques for preparation of tissue and novel methods for studying vital cells in "kinesis", you sense the flavour of the future of lung cancer which is captured in this book.
Inhaltsverzeichnis
Histopathologic typing of lung cancer Etiologic and epidemiologic features.- Squamous cell carcinoma and undifferentiated large cell carcinoma of lung: similarities and differences.- Adenocarcinoma: clinical significance of subtyping and other morphologic factors.- Pathology of small cell carcinoma of the lung:changing concepts.- Small cell carcinomas versus (atypical) carcinoids.- Intra- and interobserver problems in the histopathologic classification of malignant lung tumors.- Differential diagnosis of metastatic lesions in the lung.- Cytology and lung cancer.- Immunocytochemical assessment of lung tumors.- Critical evaluation of new techniques in the morphological diagnosis of lung cancer.- Flow cytometric DNA analysis in the study of small cell carcinoma of the lung.- Clinical applications of the biologic properties of small cell lung cancer.- Peptide hormones in lung cancer.- Mechanisms of oncogenesis.- Adhesion mechanisms in liver metastasis.- Application of monoclonal antibodies in imaging and therapy.- Current concepts in the therapy of small cell lung cancer.- Index of subjects.
