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Over the past decade, techniques have been developed and implemented to observe metabolism noninvasively in localized regions of intact, living experimental animals and humans through the use of magnetic resonance spectroscopy (MRS). At the same time, magnetic resonance imaging (MRI) techniques developed in the 1970s and refined in this decade have been increasingly applied as a powerful clinical tool to probe human anatomy. Because of the unusual metabolic and physiologic characteristics of malignant tissues, oncology has been one of the primary focuses of the application of both MRS and MRI. Although considerable progress has been made in oncologic applications of magnetic resonance (MR), further research is needed to realize the full potential of MR in this area. Consequently, the 21st Annual Detroit Cancer Symposium entitled "Magnetic Resonance in Experimental and Clin ical Oncology" was organized to provide a forum for researchers in the field to report the state of the art of MRS and MRI in oncol ogy, to discuss future goals for MRS and MRI in oncology, and to define the research needed to meet those goals. The major emphasis of the symposium was on MRS due to both the recent widespread availability of clinical MRS instrumentation and the extensive amount of animal MRS research performed over the past half decade.
Inhaltsverzeichnis
1. 31P and 13C NMR Studies of Acute and Chronic Adriamycin Cardiotoxicity.- 2. Relationship of 31P NMR Measurements to Tumor Biology.- 3. Measurement of Tumor Blood Flow by Deuterium Nuclear Magnetic Resonance Spectroscopy: Application to Murine Rif-1 Tumor.- 4. Metabolic and Physiological Responses of Mammary Carcinoma in the Mouse and Normal Brain Tissue in the Rat to Photodynamic Therapy.- 5. 31P and 2H MRS Studies of Flavone Acetic Acid and Analogues.- 6. 13C and 31P NMR Studies of Prostate Tumor Metabolism.- 7. Use of 1H MRS of Plasma and Tissue in Cancer Detection and Management.- 8. Quantification of 31P NMR In Vivo Spectra.- 9. 31P NMR Studies of Superficial Murine and Human Tumors.- 10. In Situ 31P-MRS as a Potential Predictor for Therapeutic Response of Human Neoplasms.- 11. Integrated Magnetic Resonance Imaging and 31P-Magnetic Resonance Spectroscopy of Soft Tissue Masses.- 12. Preliminary 31P MR Studies of Human Tumors.- 13. Combined MRI and 31P MRS for Diagnosis of Bone and Soft Tissue Lesions.- 14. A Comparison of the Potential Roles of Pet and MRS in Experimental and Clinical Oncology.- 15. MRI in the Diagnosis of Malignant Brain Tumors.- 16. Magnetic Resonance Imaging in the Patient with Cancer.- 17. MRI of Hematologic Diseases: Marrow Imaging.- 18. MRI of Breast Tumors: The Role of Image Processing.
Zusammenfassung
Proceedings of the 21st Annual Detroit Cancer Symposium, Detroit, Michigan, April 13-14, 1989
