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Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in "cancer stem cells" has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.
Inhaltsverzeichnis
Basic Background.- Telomeres and Telomerase in Humans.- Telomere-Binding Proteins in Humans.- Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms.- Telomere Dysfunction and the DNA Damage Response.- Alternative Lengthening of Telomeres in Human Cells.- Mouse Model: Telomeres and Telomerase in Stem Cell and Cancer.- Telomeres and Telomerase in Human Cancers.- Role of Telomeres and Telomerase in Cancer.- Diagnostic Value I: Solid Tumors.- Diagnostic Value II: Hematopoietic Malignancies.- Therapeutic Targets and Drugs I: Telomerase and Telomerase Inhibitors.- Therapeutic Targets and Drugs II: G-Quadruplex and G-Quadruplex Inhibitors.- Therapeutic Targets and Drugs III: Tankyrase 1, Telomere-Binding Proteins, and Inhibitors.- Therapeutic Targets and Drugs IV: Telomerase-Specific Gene and Vector-Based Therapies for Human Cancer.- Experimental Protocols.- Protocol I: Telomerase Activity and Telomerase Expression.- Protocol II: Importance and Methods of Telomere G-Tail Length Quantification.- Protocol III: Detection of Alternative Lengthening of Telomeres.
Zusammenfassung
Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.
