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Der programmierte Zelltod, auch Apoptosis genannt, hält die Biologen gegenwärtig besonders in Atem -man verspricht sich Aufschlüsse über Alterungsprozesse von Organismen und beispielsweise über Entstehung und Wachstum von Tumoren. Dieses hervorragende, interdisziplinär orientierte Werk trägt dem Rechnung und faßt die neuesten Forschungsergebnisse zusammen, die man bisher mühsam in Originalarbeiten suchen mußte. Gleichermaßen geeignet für fortgeschrittene Studenten und Einsteiger in dieses Gebiet. (05/98)
Inhaltsverzeichnis
THE PHENOMENON OF CELL DEATH.The Evolutionary Origin and Role of Programmed Cell Death in Single-Celled Organisms: A New Viewat Executioners, Mitochondria, Host-Pathogen Interactions, and the Role of Death in the Process of Natural Selection (J. Ameisen).The Reactions of Cells to Lethal Injury: Oncosis and Necrosis-The Role of Calcium (B. Trump&I. Berezesky).The Study of Cell Death by the Use of Cellular and Developmental Models (Z. Zakeri).Genetic Approaches to Programmed Cell Death in C. Elegans (A. Gartner&M. Hengartner).Cell Death in Plants (R. Mittler).THEMES AND APPROACHES TO CELL DEATH.The Cutting Edge: Caspases in Apoptosis and Disease (V. Cryns&J. Yuan).Endonuclease Activities and Apoptosis (M. Sikorska&P. Walker).CELL DEATH WHEN MITOSIS IS HIGH AND EVANESCENCE IS DESIRABLE.Apoptotic Signaling Pathways in Lymphocytes (B. Osborne).Regulation of Immune Responses by Immune Directed Cell Death (M. Newell&M. Vincent).Apoptosis in Autoimmunity (R. Budd).Aids and Cell Death (T. Finkel&C. Casella).CELL DEATH IN LONG-LIVED CELLS.Apoptosis of Tissues of the Eye During Development and Disease (D. Papermaster).Signal Transduction and Neuronal Cell Death During Development and Disease (R. Birge, et al.).Cell Death in Alzheimer's Disease (C. Cotman, et al.).Regulation of Apoptosis by Cellular Interactions with the Extracellular Matrix (J. Tidball&D. Albrecht).THE CLINICAL RELEVANCE OF APOPTOSIS.Cell Death and Species Propagation: Molecular and Genetic Aspects of Apoptosis in the Vertebrate Female Gonad (J. Tilly).Assessment of Apoptosis in Tumor Growth: Importance in Clinical Oncology and Cancer Therapy (L. Benítez-Bribiesca).Index.
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"This book provides a good background and summary of the scientific challenges in this very complex area of science and would be most appropriate for researchers new to this field." --The Quarterly Review of Biology, June 1999
