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Informationen zum Autor Alexei Verkhratsky is Professor of Neurophysiology and Chairman of the Division of Neuroscience at the University of Manchester, UK. Arthur Butt is Professor of Cellular Neurophysiology, Department of Pharmacy and Biomedical Sciences, University of Portsmouth, UK. Klappentext Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells.Coverae includes:* the morphology and interrelationships between glial cells and neurones in different parts of the nervous systems* the cellular physiology of the different kinds of glial cells* the mechanisms of intra- and inter-cellular signalling in glial networks* the mechanisms of glial-neuronal communications* the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system* the cellular and molecular mechanisms of metabolic neuronal-glial interactions* the role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson'sNeuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it.* An up-to-date and fully referenced text on the most numerous cells in the human brain* Detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system* Describes the role og glial cells in neuropathology* Focus boxes highlight key points and summarise important facts* Companion website with downloadable figures and slides Zusammenfassung This comprehensive advanced text on the biology and pathology of glial cells--the most numerous cells in the brain and an emerging field in neuroscience--offers detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system. Inhaltsverzeichnis Preface xvii About the Authors xxi Abbreviations xxv About the Companion Website xxxii 1 History of Neuroscience and the Dawn of Research in Neuroglia 1 1.1 The miraculous human brain: localising the brain functions 1 1.2 Cellular organisation of the brain 10 1.3 Mechanisms of communications in neural networks 14 1.4 The concept of neuroglia 27 1.5 Beginning of the modern era 47 1.6 Concluding remarks 49 References 49 2 General Overview of Signalling in the Nervous System 59 2.1 Intercellular signalling: wiring and volume modes of transmission 59 2.2 Cellular signalling: receptors 62 2.3 Intracellular signalling: second messengers 67 2.4 Calcium signalling 67 2.5 Concluding remarks 72 3 Neuroglia: Definition, Classification, Evolution, Numbers, Development 73 3.1 Definition of neuroglia as homeostatic cells of the nervous system 74 3.2 Classification 75 3.3 Evolution of neuroglia 76 3.4 Numbers: how many glial cells are in the brain? 93 3.5 Embryogenesis and development of neuroglia in mammals 96 3.6 Conc...
