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Informationen zum Autor RICHARD F. DODS, PhD, D.ABCC, has studied, taught, and written about diabetes mellitus for many years, beginning as a research associate at New York University Medical School. As Director of Clinical Chemistry at the Louis A. Weiss Memorial Hospital, Dr. Dods published pioneering papers on the use of HbA1c as a test for monitoring diabetes mellitus. Later, he established his own company, Clinical Laboratory Consultants, which advised hospital and commercial laboratories on the implementation and interpretation of assays and the use of instruments for the diagnosis and monitoring of disease, including diabetes. Klappentext A clear explanation of the cause, diagnosis, and treatment of diabetes Written for a broad range of readers, including students, researchers, policymakers, health care providers, and diabetes patients and caregivers, this book explains the underlying biochemistry and physiology of diabetes mellitus. Each chapter contains a glossary that defines key terms, a summary that highlights essential concepts discussed in each section of the chapter, as well as a set of simple problems to help readers gain a richer and deeper understanding of diabetes, from its history to treatment options. Understanding Diabetes begins with an overview of the disease, its worldwide prevalence and cost, and its connection to the global obesity epidemic. The author then explores the history of diabetes, including the first documented description of the disease dating back to 3400 BCE in Ancient Egypt. The next chapter, A Glucose Metabolism Primer, sets forth the pathways for the metabolism of glucose. Next, the book covers: Regulation of glucose metabolism and glucose metabolism gone wrong Diabetes classification system Diagnosis, including current laboratory tests Complications, such as retinopathy, neuropathy, and cardiovascular disease Hereditary transmission Prevention and treatment, including emerging research Although a cure has still not been found, this book demonstrates that researchers are continuing to make major breakthroughs on all fronts in the fight against diabetes, including a better understanding of its causes and an improved ability to diagnose and treat the disease. "Without doubt, this is an interesting and unique book with major merits. It succeeds in closing a gap not filled by other books and in giving fresh insights into biochemistry." ("ChemMedChem", 1 August 2013) Zusammenfassung A clear explanation of the cause, diagnosis, and treatment of diabetes Written for a broad range of readers, including students, researchers, policymakers, health care providers, and diabetes patients and caregivers, this book explains the underlying biochemistry and physiology of diabetes mellitus. Inhaltsverzeichnis PREFACE xvii 1 DIABETES MELLITUS: A PANDEMIC IN THE MAKING 1 Diabetes Prevalence and Cost in the United States 2 A Dire Prediction Based on Alarming Data 2 The Increase of Diabetes in Youths 4 The Cost 6 Diabetes Prevalence and Cost Worldwide 7 A Worldwide Epidemic 7 Numbers of Cases of Diabetes 7 Cost 7 Obesity and Overweight; Another Epidemic in the United States 9 A Parallel Pandemic 9 Definitions of Overweight and Obesity 9 Overweight and Obesity among Adults in the United States 9 Obesity and Overweight among Children and Adolescents in the United States 12 Overweight and Obesity Worldwide 14 Overweight and Obesity Globally in Adults 14 Overweight and Obesity in Children 16 The Relationship Between Obesity and Diabetes 16 Projects and Questions 18 Glossary 18 References 19 2 AN EARLY HISTORY OF DIABETES MELLITUS 23 Translation 24
Inhaltsverzeichnis
PREFACE xvii
1 DIABETES MELLITUS: A PANDEMIC IN THE MAKING 1
2 AN EARLY HISTORY OF DIABETES MELLITUS 23
3 A PRIMER: GLUCOSE METABOLISM 55
3-Phosphoglycerate Kinase / 78
4 REGULATION OF GLUCOSE METABOLISM 113
5 GLUCOSE METABOLISM GONE WRONG 153
6 CLASSIFICATION SYSTEM FOR DIABETES MELLITUS 183
7 DIAGNOSIS OF DIABETES MELLITUS 201
8 COMPLICATIONS OF DIABETES MELLITUS AND THEIR PATHOPHYSIOLOGY 249
9 HEREDITARY TRANSMISSION OF DIABETES MELLITUS 283
10 TREATMENT 323
APPENDIX A 357
APPENDIX B 361
INDEX 377
Bericht
"I think that it would be of most use to young diabetologists and chemical pathologists early in their training to ensure that they understand the foundations and principles of the condition they are seeing every day." (Diabetes Update, 1 October 2013)
"Without doubt, this is an interesting and unique book with major merits. It succeeds in closing a gap not filled by other books and in giving fresh insights into biochemistry." (ChemMedChem, 1 August 2013)
