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In 1981, the Institute of Anesthesiology at the Ludwig Maximil ian University of Munich organized a first international sympo sium on inhalation anesthetics. In 1982, the most important con tributions were published in the series Anaesthesiology and Inten sive Care Medicine. At that time, the interest of European anes thesiologists was focused on isoflurane, which had just been in troduced for clinical purposes. Studies on this product had al ready been appearing for years in the American literature. This book deals once more with all three inhalation anesthetics, but places particular emphasis on isoflurane. In contrast to the situa tion in 1981, extensive experimental and clinical investigations on isoflurane have by now become available in the European litera ture. From its conception, the objective of this symposium was not to discuss the relative value of inhalation anesthesia (bal anced anesthesia) as compared with intravenous anesthesia. On the contrary, the major effects and interactions of isoflurane were to be explored. The side effects and their relative significance in different patient groups were also of interest. eurrent knowledge concerning a range of topics related to inhalation anesthetics (es pecially isoflurane) was to be presented in a comprehensive and critical manner. The effects of isoflurane on the cardiovascular system were the focus of interest during the symposium and are accordingly dealt with extensively in this volume. The comparative effects on cor onary perfusion of isoflurane, enflurane, and halothane are de scribed in detail.
Inhaltsverzeichnis
List of Contents.- Clinical Significance of Biotransformation.- Uptake, Distribution, and Elimination of Volatile Anesthetics.- Pharmacokinetics and MAC: Practical Implications for Dosage of Volatile Anesthetics.- Comparative Pharmacodynamics of Halogenated Anesthetics: Quantitative EEG Analysis to Objectify Central Nervous Effects.- Pharmacokinetics of Inhalation Anesthetics Studied with a Feedback-Controlled Closed System.- Metabolism and Acute Toxicity of Volatile Anesthetics.- Present Status of Organotoxicity of Inhalation Anesthetics.- The Influence of Volatile Anesthetics on Cerebral Blood Flow and Cerebral Autoregulation.- The Influence of Equipotent Concentrations of Inhalation Anesthetics on the Human Electroencephalogram.- Anesthesia and the Kidney.- Changes in Hemodynamics, Regional Organ Blood Flow, and Tissue Oxygen Consumption Under Isoflurane and Enflurane.- Interactions of Volatile Anesthetics with Epinephrine, ß-Receptor Antagonists and Calcium Channel Blockers.- Inhalation Anesthetics and Malignant Hyperthermia.- Volatile Anesthetics and Their Effects on the Respiratory System.- The Influence of Inhalation Anesthetics on Respiratory Mechanics.- Aspects of the Effects of Enflurane on Cardiovascular Control.- Cardiodynamics During Rapid Volume Expansion and Function of Chronically Ischemic Myocardium Under Isoflurane: A Study in Chronically Instrumented Dogs.- Effects of Inhalation Anesthetics on Coronary Blood Flow and O2 Supply of the Myocardium.- Effects of Isoflurane and Enflurane on Oxygen Supply and Microcirculation of the Myocardium.- Blood Flow and Oxygen Supply of the Myocardium Under Isoflurane and Enflurane.- Myocardial Ischemia During Inhalation Anesthesia in Surgical Patients with Coronary Artery Disease.- Regional Changes During MyocardialIschemia: An Animal Experimental Study.- Volatile Anesthetics and Heart Failure.- Inhalation Anesthesia and Myocardial Function: Pharmacodynamic and Pharmacokinetic Aspects.- Treatment of Hypertensive Crisis.- Inhalation Anesthetics in Vascular Surgery.- Inhalation Anesthesia in Geriatric Patients.- Volatile Anesthetics in Paediatrics, Today and Tomorrow.- Volatile Anesthetics for Combination with Epidural Anesthesia.- Volatile Anesthetics in Pregnancy and Obstetrics.
Über den Autor / die Autorin
Professor Dr. med. Klaus Peter, gebroen 1938, Medizinstudium in Heidelberg, ab 1976 an der LMU Lehrstuhlinhaber für Anästhesiologie und Direktor der Klinik für Anästhesiologie (1976 - 2007); Dekan der Medizinischen Fakultät (1989 - 2005) und Ärztlicher Direktor des Klinikums (1983 89, 2005 -2007). Leitete den Strukturausschuss für die Errichtung der Medizinischen Forschungs- und Ausbildungsstätte der Universität Regensburg (1988 -1993); seit 2013 Vorsitzender der Projektgruppe zur Gründung des Universitätsklinikums Augsburg.
