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Gene transfer technology is a powerful tool for increasing
our understandingof brain functions. It is also the basis
of gene therapy, which is now technically possible for the
correction of many human diseases, including several
disorders of the nervous (and muscular) system such as
Alzheimer's disease, Parkinson's disease, and dystrophy.
This volume,which contains the proceedings of a symposium
of the Fondation Ipsen, provides a unique view of the state
of the art on different transgenes, vectors, target cells,
and clinical applications related to the nervous system.
Inhaltsverzeichnis
Somatic Cell Gene Therapy.- Delivery of Nerve Growth Factor Within the Rat Brain Using Genetically Modified Cells.- A Potential Approach to Gene Therapy of Cancer.- Phenotypic Plasticity and Neural Grafting.- The Sympathoadrenal Progenitor of the Neural Crest: Basic Biology and Therapeutic Potential.- Lineage, Migration, and Phenotype in Avian Optic Tectum: Analysis with Recombinant Retroviral Vectors.- Immortal Mammalian Neuronal Stem Cells Differentiate after Implantation into the Developing Brain.- Establishment of Clonal Cell Lines for the Study of Neural Function and Dysfunction.- Resistance of SOD-Transgenic Mice to Oxidative Stress.- Gene Transfer into the Nervous System using Recombinant Herpes Virus Vectors.- Development of Herpes Simplex Virus as a Gene Transfer Vector for the Central Nervous System.- Dystrophin mRNA Processing in the Canine Homologue of Duchenne Muscular Dystrophy: An Authentic Model for Gene Therapy.- Gene Transfer of a Murine Dystophin Minigene Construct.- Gene Therapy in Animal Models of Neurological Disorders.- Neurotrophins and their Receptors.- Regulation of the Human Neurofilament Light and Heavy Genes in Transgenic Mice.
