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It is now apparent that several fields of investigation areconverging upon each other as the goal of finding apractical way to prevent cancer is pursued. The presentmonograph represents the efforts of an interdisciplinary ESOTask Force that was convened to assess interactions ofpeptide growth factors and steroid-like molecules in theprevention of cancer. Each of the participants in the TaskForce represents a differentscientific discipline, and themonogrph is intended to be a synthesis of their differentapproaches to the common problem of cancer prevention.It is hoped that the reader will find this monograph to beof use in the evaluation of both preclinical and clinicalapproaches to the major issues that face us inchemoprevention. It is clear that prevention of cancer is anidea whose time has come, and the problem now is toimplement the most effective approaches toward achieving thedesired goals.
Inhaltsverzeichnis
Concepts of Preneoplasia for the Goal of Cancer Prevention.- Steroids, Retinoids, and their Mode of Action.- Epidermal Growth Factor, Glucocorticoid Hormones and Prolactin Act Sequentially in the Induction of Milk Protein Gene Expression.- Interactions of Retinoids and Transforming Growth Factor-Beta in the Chemoprevention of Cancer.- Growth Regulatory Networks in the Prostate.- Prospects for the Chemoprevention of Breast Cancer.
Zusammenfassung
It is now apparent that several fields of investigation are
converging upon each other as the goal of finding a
practical way to prevent cancer is pursued. The present
monograph represents the efforts of an interdisciplinary ESO
Task Force that was convened to assess interactions of
peptide growth factors and steroid-like molecules in the
prevention of cancer. Each of the participants in the Task
Force represents a differentscientific discipline, and the
monogrph is intended to be a synthesis of their different
approaches to the common problem of cancer prevention.
It is hoped that the reader will find this monograph to be
of use in the evaluation of both preclinical and clinical
approaches to the major issues that face us in
chemoprevention. It is clear that prevention of cancer is an
idea whose time has come, and the problem now is to
implement the most effective approaches toward achieving the
desired goals.
