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This volume will explore the latest findings in research into the genetics of breast and reproductive cancers, covering the epidemiological aspects of these cancers, their etiology, the effect of environment on genes and cancer etiology, and how research in this area can lead to development of preventative measures and treatments.
Inhaltsverzeichnis
Recognition of Hereditary Breast and Reproductive Cancer Syndromes.- Cancer genetics in the clinic: The challenges and responsibilities of counseling women at risk .- Hereditary Breast and Ovarian Cancer Syndrome.- Modifiers of risk of hereditary breast and ovarian cancer.- Recent advances in under standing the cellular functions of BRCA1 and BRCA2.- Other hereditary breast and ovarian cancer syndromes and their genes.- Endometrial and ovarian cancer in patients with HNPCC Syndrome.- Somatic alterations and implications in breast epithelial cells.- Somatic alterations and implications in ovarian epithelial cells.- High frequency low penetrance alleles.- Host and viral genetics and risk of cervical cancer .- Estrogen metabolizing gene polymorphisms, genetic susceptibility, and pharmacogenomics.- The future of discoveries in breast and reproductive cancers: the genome and epigenetics.
Über den Autor / die Autorin
Piri L. Welcsh, PhD is a Research Assistant Professor in the Department of Medicine, Division of Medical Genetics at the University of Washington. She received her PhD in Molecular Genetics from The Ohio State University. It was during this time that the seminal paper in which Dr. Mary-Claire King demonstrated that a single gene on chromosome 17, later known as BRCA1, was responsible for many breast and ovarian cancers was published. During Postdoctoral studies at the University of Texas Southwestern Medical Center in Dallas, Dr. Welcsh worked under the guidance of Dr. Anne M. Bowcock and collaborated with Drs. Mary-Claire King and Francis Collins in an attempt to clone BRCA1. Shortly after the gene encoding BRCA1 was identified, Dr. Welcsh joined the research group of Dr. King at the University of Washington where she conducted studies designed to elucidate the biological function of BRCA1. She is currently an independent investigator whose current research goals include the identification and characterization of both genetic and epigenetic mechanisms critical to the development of breast and ovarian cancer.
Zusammenfassung
This volume will explore the latest findings in research into the genetics of breast and reproductive cancers, covering the epidemiological aspects of these cancers, their etiology, the effect of environment on genes and cancer etiology, and how research in this area can lead to development of preventative measures and treatments.
