Mehr lesen
Optimized by nature over the millennia, enzymes are catalysts that play a crucial role in the transformation and degradation of essential molecules in living organisms. Biocatalysis and biotransformations have been part of our daily lives for thousands of years, two obvious examples being the production of wine and vinegar. Most of the enzymes used in biocatalysis today are of microbial origin (bacteria, fungi or yeast), while a few are of plant or mammal origin.
Edited by a highly knowledgeable team with a tremendous amount of experience in organic synthesis, catalysis and biocatalysis as well as their applications, this new edition retains the successful concept of its predecessors, while the contents are very much focused on new developments in the field.
From the contents:
Concepts in biocatalysis
Discovery of enzymes
Rational design of enzymes
Directed evolution of enzymes
Production of enzymes
Reaction and process engineering
Hydrolysis and formation of C-O BONDS
Hydrolysis and formation of C-N BONDS
Formation and cleavage of C-C-BONDS
Reductions
Oxidations
All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach.
A must for all chemists and biotechnologists, this is the standard reference in the field.
Inhaltsverzeichnis
INTRODUCTION
CONCEPTS IN BIOCATALYSIS
DISCOVERY OF ENZYMES
RATIONAL DESIGN OF ENZYMES
DIRECTED EVOLUTION OF ENZYMES
PRODUCTION OF ENZYMES
REACTION AND PROCESS ENGINEERING
HYDROLYSIS AND FORMATION OF C-O BONDS
Hydrolysis and Formation of Carboxylic Acid Esters
Hydrolysis and Formation of Epoxides
Hydrolysis and Formation of Glycosidic Bonds
Addition and Elimination of Water to C=C Bonds
HYDROLYSIS AND FORMATION OF C-N BONDS
Hydratation of Nitriles to Amides
Hydratation of Nitriles to Acids
Hydrolysis of Amides
Hydrolysis and Formation of Hydantoins
Hydrolysis and Formation of Peptides
Addition of Ammonia and Amines to C=C Bonds
Transaminases in Organic Synthesis
FORMATION AND CLEAVAGE OF C-C-BONDS
Aldolreactions
Acyloin- and Benzoin Condensations
Cleavage and Formation of Cyanohydrines
Hydrolysis and Formation of P-O Bonds
REDUCTIONS
Ketones and Aldehydes to Alcohols
Enzymatic Reduction of C=C-Double Bonds
Reductive Aminations
OXIDATIONS
Oxifunctionalization of C-H Bonds
Oxifunctionalization of C-C-Multiple Bonds
Oxidation of Alcohols, Aldehydes and Acids
Baeyer-Villiger-Oxidations
Oxidation of Aromatic Compounds
Oxidation of C-N Bonds
Oxidation at Sulfur and Oxidation of Amino Groups
Halogenation
Isomerizations
MISCELLANEOUS
Enzymatic Promiscuity
Catalytic Antibodies
Coupled Enzyme Reactions and Pathway Engineering
Combined Chemo-Enzymatic Reactions
Biocatalysis in Material Sciences
TABULAR SURVEY OF AVAILABLE ENZYMES
