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Myelodysplastic syndromes are to the bone marrow what pneumonia is to the lungs; the response of an organ to a variety of etiologic insults like aging, toxic exposure, infections and auto-immunity. Among infectious causes alone, pneumonia could be the result of a variety of possible pathogens including bacterial, viral, tuberculous or fungal agents. Similarly, MDS cannot be treated as a single disease. Attempts to harness the inherent complexity of MDS by devising `classifications' which group the various syndromes as one disease is as misguided as saying that a pneumonia is not infectious because it did not respond to antibiotics. Progress in the field will occur faster when we re-analyze this premise. Therefore, until a clearer picture of the disease emerges it is best to treat each of the MDS syndromes as a separate entity. Having no classification is better than a misleading one.
Cancer research has been notable for its periodic cycles of promise and hope, followed by defeat and disappointments. It is not that there is no solution, but that the problem has not been identified precisely. This book is our attempt to define the most crucial questions related to MDS that need to be addressed immediately through logic, analysis and rigorous experimentation. If the emerging problems appear daunting, then instead of being overwhelmed by them, we should follow the advice of the great 20th century thinker Antonio Gramsci, `pessimism of the intellect must be faced with the optimism of will'.
Sommario
1. Evolving Concepts in Myelodysplastic Syndromes.- 2. In Vitro Biology of the Hematopoietic System in Myelodysplastic Syndromes.- 3. Biology of Stem & Myeloid Progenitor Cells in Myelodysplastic Syndromes.- 4. Novel In Vitro Culture and Ultrastructural Techniques to Study the Biology of Myelodysplastic Syndromes (MDS).- 5. The Monocytic Component in Myelodysplastic Syndromes.- 6. Cytokines and MDS.- 7. Apoptosis in MDS: A New Perspective.- 8. Molecular, Cytogenetic and Genetic Abnormalities in MDS and Secondary AML.- 9. Stem Cell Transplantation for Myelodysplasia.- 10. Myelodysplastic Syndromes Complicating Hematopoietic Stem Cell Transplantation.- 11. Evolution of Secondary Hematologic Disorders: PreMDS?MDS?sAML.- 12. The Impact of Biology on the Treatment of Secondary AML.- 13. Special Clinical Concerns/Problems in the Management of MDS and Secondary Acute Myeloid Leukemias.- 14. MDS and Secondary AML: An Evolutionary Perspective.
Riassunto
Myelodysplastic syndromes are to the bone marrow what pneumonia is to the lungs; the response of an organ to a variety of etiologic insults like aging, toxic exposure, infections and auto-immunity. Among infectious causes alone, pneumonia could be the result of a variety of possible pathogens including bacterial, viral, tuberculous or fungal agents. Similarly, MDS cannot be treated as a single disease. Attempts to harness the inherent complexity of MDS by devising `classifications' which group the various syndromes as one disease is as misguided as saying that a pneumonia is not infectious because it did not respond to antibiotics. Progress in the field will occur faster when we re-analyze this premise. Therefore, until a clearer picture of the disease emerges it is best to treat each of the MDS syndromes as a separate entity. Having no classification is better than a misleading one.
Cancer research has been notable for its periodic cycles of promise and hope, followed by defeat and disappointments. It is not that there is no solution, but that the problem has not been identified precisely. This book is our attempt to define the most crucial questions related to MDS that need to be addressed immediately through logic, analysis and rigorous experimentation. If the emerging problems appear daunting, then instead of being overwhelmed by them, we should follow the advice of the great 20th century thinker Antonio Gramsci, `pessimism of the intellect must be faced with the optimism of will'.
