Gas Chromatography and Mass Spectrometry - A Practical Guide

Klappentext The Second Edition of Gas Chromatography and Mass Spectrometry: A Practical Guide follows the highly successful first edition by F.G. Kitson! B.S. Larsen! and C.N. McEwen (1996). It covers separation conditions for numerous compound types! instructions for the interpretation of mass spectral data! extensive correlations of ion masses and neutral losses with possible structures! and examples of mass spectra to aid in structure determination. Zusammenfassung Covers the practical instruction necessary for successful operation of GC/MS equipment. This title reviews the advances in instrumentation! ionization methods! and quantitation. It includes troubleshooting techniques and a variety of additional information useful for the GC/MS practitioner. Inhaltsverzeichnis Preface Acknowledgments Section 1 THE FUNDAMENTALS OF GC/MS 1 Introduction and History 2 Gas Chromatography 3 The GC/MS Interface 4 Mass Spectrometry Instrumentation 5 Mass Spectral Data Interpretation 6 Quantitation with GC/MS Section 2 GC CONDITIONS, DERIVATIZATION, AND MASS SPECTRAL INTERPRETATION OF SPECIFIC COMPOUND TYPES 7 Acids 8 Alcohols 9 Aldehydes 10 Amides 11 Amines 12 Amino Acids 13 Common Contaminants 14 Drugs and Their Metabolites 15 Esters 16 Ethers 17 Fluorinated Compounds 18 Gases 19 Glycols 20 Halogenated Compounds (Other Than Fluorinated Compounds) 21 Hydrocarbons 22 Isocyanates 23 Ketones 24 Nitriles 25 Nitroaromatics 26 Nitrogen-Containing Heterocyclic Compounds 27 Nucleosides (TMS Derivatives) 28 Pesticides 29 Phenols 30 Phosphorus Compounds 31 Plasticizers and Other Polymer Additives (Including Phthalates) 32 Prostaglandins (MO-TMS Derivatives) 33 Solvents and Their Impurities 34 Steroids 35 Sugars (Monosaccharides) 36 Sulfur Compounds Section 3 APPENDICES Appendix A Definitions of Terms Related to Gas Chromatography Appendix B Definitions of Terms Related to Mass Spectrometry Appendix C Atomic Masses and Isotope Abundances and Other Information for the Determination of an Elemental Composition from Isotope Peak Intensity Ratios Appendix D X+1 and X+2 Values for Ions Containing Atoms of C and H Based on Isotope Contributions Appendix E Isotope Peak Patterns for Ions Containing Atoms of Cl and/or Br Appendix F Steps to Follow in the Determination of an Elemental Composition Based on Isotope Peak Intensity Ratios Appendix G Derivatization in GC/MS Appendix H Points of Comparison of LC/MS vs GC/MS Appendix I List of Available EI Mass Spectral Databases Appendix J Information Required for Reporting a GC/MS Analysis Appendix K Third-Party Software for Use with GC/MS Appendix L GC Installation and Maintenance Appendix M Troubleshooting Common GC Problems Appendix N Maintenance, Operating Tips, and Troubleshooting for Mass Spectrometers Appendix O Mixtures for Determining Mass Spectral Resolution Appendix P Cross-Index Chart for GC Stationary Phases Appendix Q Ions for Determining Unknown Structures Index...

Sommario

Preface
Acknowledgments

Section 1 THE FUNDAMENTALS OF GC/MS
1 Introduction and History
2 Gas Chromatography
3 The GC/MS Interface
4 Mass Spectrometry Instrumentation
5 Mass Spectral Data Interpretation
6 Quantitation with GC/MS

Section 2 GC CONDITIONS, DERIVATIZATION, AND MASS SPECTRAL INTERPRETATION OF SPECIFIC COMPOUND TYPES
7 Acids
8 Alcohols
9 Aldehydes
10 Amides
11 Amines
12 Amino Acids
13 Common Contaminants
14 Drugs and Their Metabolites
15 Esters
16 Ethers
17 Fluorinated Compounds
18 Gases
19 Glycols
20 Halogenated Compounds (Other Than Fluorinated Compounds)
21 Hydrocarbons
22 Isocyanates
23 Ketones
24 Nitriles
25 Nitroaromatics
26 Nitrogen-Containing Heterocyclic Compounds
27 Nucleosides (TMS Derivatives)
28 Pesticides
29 Phenols
30 Phosphorus Compounds
31 Plasticizers and Other Polymer Additives (Including Phthalates)
32 Prostaglandins (MO-TMS Derivatives)
33 Solvents and Their Impurities
34 Steroids
35 Sugars (Monosaccharides)
36 Sulfur Compounds

Section 3 APPENDICES
Appendix A Definitions of Terms Related to Gas Chromatography
Appendix B Definitions of Terms Related to Mass Spectrometry
Appendix C Atomic Masses and Isotope Abundances and Other Information for the Determination of an Elemental Composition from Isotope Peak Intensity Ratios
Appendix D X+1 and X+2 Values for Ions Containing Atoms of C and H Based on Isotope Contributions
Appendix E Isotope Peak Patterns for Ions Containing Atoms of Cl and/or Br
Appendix F Steps to Follow in the Determination of an Elemental Composition Based on Isotope Peak Intensity Ratios
Appendix G Derivatization in GC/MS
Appendix H Points of Comparison of LC/MS vs GC/MS
Appendix I List of Available EI Mass Spectral Databases
Appendix J Information Required for Reporting a GC/MS Analysis
Appendix K Third-Party Software for Use with GC/MS
Appendix L GC Installation and Maintenance
Appendix M Troubleshooting Common GC Problems
Appendix N Maintenance, Operating Tips, and Troubleshooting for Mass Spectrometers
Appendix O Mixtures for Determining Mass Spectral Resolution
Appendix P Cross-Index Chart for GC Stationary Phases
Appendix Q Ions for Determining Unknown Structures
Index

Relazione

"The authors have kept this book relevant and timely and have achieved their goal of providing useful information for practitioners. They understand what those who actually use GC/MS need, and continue to add appendixes of numerical information (increased from 12 to 17 in this revision).The entire book has been updated and improved where needed; for example, chapter 6, covering the challenging topic of quantitation, has been "completely reworked." Sparkman and his collaborators continue to write high-quality books that are extremely useful, precise, and interesting to both novices and experienced scientists. Summing Up: Highly recommended. Upper-division undergraduates through professionals/practicioners."
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Dettagli sul prodotto

• Autori: Fulton G. Kitson, Kitson Fulton G., O. David Sparkman, Zelda Penton, Zelda E. Penton, Penton Zelda, O David Sparkman, O David (Antioch Sparkman, O. David Sparkman, O. David (Antioch Sparkman, O. David/ Penton Sparkman
• Editore: Academic Press London
• Lingue: Inglese
• Formato: Tascabile
• Pubblicazione: 30.10.2009, ritardato
• EAN: 9780123736284
• ISBN: 978-0-12-373628-4
• Pagine: 400
• Serie: Academic Press; Academic Press
• Categorie: Scienze naturali, medicina, informatica, tecnica > Scienze naturali, tematiche generali; SCIENCE / Chemistry / Analytic, Chromatography