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Informationen zum Autor CHING-HUNG HSU, PhD, DABT , is a Vice President at TaiGen Biotechnology Co., Ltd. His professional experience includes positions at Merck & Co., Inc., the U.S. Environmental Protection Agency, and the California Environmental Protection Agency. Dr. Hsu earned his BS from the National Taiwan University and PhD from the Massachusetts Institute of Technology. He completed his postdoctoral training at the University of California at Berkeley. Dr. Hsu is board-certified in toxicology by the American Board of Toxicology. He has published numerous professional papers, book chapters, and technical reports. Dr. Hsu serves on the Editorial Board of two international peer-reviewed journals. TODD STEDEFORD, PhD, JD, DABT, is a Toxicology Advisor and In-house Counsel for a multinational specialty chemical manufacturer. Previously, he was a human health toxicologist with the U.S. Environmental Protection Agency and an adjunct scientist with the Polish Academy of Sciences. Dr. Stedeford is board-certified in toxicology by the American Board of Toxicology and licensed to practice law in the District of Columbia and the State of Louisiana. He has authored over eighty publications including peer-reviewed scientific articles, government health assessments, legal articles, and scientific and legal book chapters. Klappentext With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous. Zusammenfassung With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. Inhaltsverzeichnis PREFACE . CONTRIBUTORS . ABBREVIATIONS AND ACRONYMS . PART I CANCER RISK ASSESSMENT, SCIENCE POLICY, AND REGULATORY FRAMEWORKS. CHAPTER 1 CANCER RISK ASSESSMENT ( Elizabeth L. Anderson, Kimberly Lowe, and Paul Turnham) . 1.1. Cancer Risk Assessment . 1.2. The Weight of Evidence (WOE) for Determining Carcinogenicity . 1.3. Risk Assessment in the 21st Century . 1.4. Applications in Risk Management . References . CHAPTER 2 SCIENCE POLICY AND CANCER RISK ASSESSMENT ( Gary E. Marchant ) . 2.1. Introduction . 2.2. Use of Risk Assessment in Regulatory Decision-Making . 2.3. Role Of Risk Assessment Guidelines . 2.4. Data Quality Requirements . 2.5. Types of Data Used in Risk Assessment . 2.6. Application of "Conservative" Assumptions and Precaution . 2.7. Conclusion . References . CHAPTER 3 HAZARD AND RISK ASSESSMENT OF CHEMICAL CARCINOGENICITY WITHIN A REGULATORY CONTEXT ( Henk Tennekes, Virginia A. Gretton, and Todd Stedeford) . 3.1. Overview . 3.2. Risk Assessment . 3.3. Regulatory Schemes for Industrial Chemicals and Biocides . 3.4. Scientific Aspects of Carcinogenic Risk Assessment . 3.5. Conclusions . References . CHAPTER 4 USE OF CANCER RISK ASSESSMENTS IN DETERMINATION OF REGULATORY ST...
