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Informationen zum Autor Xiaoyuan Chen received his PhD in chemistry from the University of Idaho and was an Associate Professor of Radiology in the School of Medicine at Stanford University before joining the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) as a senior investigator and the Laboratory of Molecular Imaging and Nanomedicine (LOMIN) as chief. He is the author of more than 200 scholarly articles and has edited one book to date. Dr. Chen's research interests include developing and validating novel molecular imaging probes (nanoparticles, antibodies, proteins, peptides, and small organic molecules) for better understanding of the biology, early diagnosis of disease, monitoring therapy response, and guiding drug discovery and development. Klappentext The cutting-edge guide on advancing the science of molecular imaging using nanoparticles Nanoplathform-Based Molecular Imaging provides rationale for using nanoparticle-based probes for molecular imaging, then discusses general strategies for this underutilized, yet promising, technology. It addresses general strategies of particle synthesis and surface chemistry, applications in computed tomography optical imaging, magnetic resonance imaging, ultrasound, multimodality imaging, theranostics, and finally, the clinical perspectives of nanoimaging. This comprehensive volume summarizes the opinions of those in the forefront of research and describes the latest developments by emphasizing fundamentals and initiating hands-on application. Zusammenfassung The cutting-edge guide on advancing the science of molecular imaging using nanoparticles Nanoplathform-Based Molecular Imaging provides rationale for using nanoparticle-based probes for molecular imaging! then discusses general strategies for this underutilized! yet promising! technology. Inhaltsverzeichnis Preface ix Acknowledgments xi Contributors xiii PART I BASICS OF MOLECULAR IMAGING AND NANOBIOTECHNOLOGY 1. Basic Principles of Molecular Imaging 3 Sven H. Hausner 2. Synthesis of Nanomaterials as a Platform for Molecular Imaging 25 Jinhao Gao, Jin Xie, Bing Xu, and Xiaoyuan Chen 3. Nanoparticle Surface Modification and Bioconjugation 47 Jin Xie, Jinhao Gao, Mark Michalski, and Xiaoyuan Chen 4. Biodistribution and Pharmacokinetics of Nanoprobes 75 Nagesh Kolishetti, Frank Alexis, Eric M. Pridgen, and Omid C. Farokhzad PART II NANOPARTICLES FOR SINGLE MODALITY MOLECULAR IMAGING 5. Computed Tomography as a Tool for Anatomical and Molecular Imaging 107 Pingyu Liu, Hu Zhou, and Lei Xing 6. Carbon Nanotube X-Ray for Dynamic Micro-CT Imaging of Small Animal Models 139 Otto Zhou, Guohua Cao, Yueh Z. Lee, and Jianping Lu 7. Quantum Dots for In Vivo Molecular Imaging 159 Yun Xing 8. Biopolymer, Dendrimer, and Liposome Nanoplatforms for Optical Molecular Imaging 183 David Pham, Ling Zhang, Bo Chen, and Ella Fung Jones 9. Nanoplatforms for Raman Molecular Imaging in Biological Systems 197 Zhuang Liu 10. Single-Walled Carbon Nanotube Near-Infrared Fluorescent Sensors for Biological Systems 217 Jingqing Zhang and Michael S. Strano 11. Microparticle- and Nanoparticle-Based Contrast-Enhanced Ultrasound Imaging 233 Nirupama Deshpande and J¿urgen K. Willmann 12. Ultrasound-Based Molecular Imaging Using Nanoagents 263 Srivalleesha Mallidi, Mohammad Mehrmohammadi, Kimberly Homan, Bo Wang, Min Qu, Timothy Larson, Konstantin Sokolov, and Stanislav Emelianov 13. MRI Contrast Agents Based on Inorganic Nanoparticles 279 Hyon Bin Na and Taeghwan Hyeon 14. Cellular Magnetic Labeling with Iron Oxide Nanoparticles 309 Seb...
