Ulteriori informazioni
Informationen zum Autor Associated with our Pigment Cell Journal, the authors are of the highest stature in their fields. Lynn Lamoreux is a mouse geneticist well known for her work in pigment system. Dorothy Bennett is an expert on growth and biology of melanocytes while Dr. Larue is an expert on melanoma. together they are some of the most respected researchers in pigment cell biology Klappentext Serving the needs of pigment cell biologists, cellular physiologists, developmental geneticists, researchers interested in melanoma and more, this new book brings to market a blend of new technologies and new insights in the fields of both pigmentation and mouse geneticists. It will include some comparative information on other organisms as well. The book is hailed for being written by 3 of the premier scientists in the field. These authors aime to present the molecular /cellular work in the context of phenotype and the interacting functions of genes that direct the development and function of one biological system. Interactions over details that can be found on the web are stressed. Overall the pigmentary systems provides a model for the study of all systems because it is a particularly well developed model. Zusammenfassung Serving the needs of pigment cell biologists, cellular physiologists, developmental geneticists, researchers interested in melanoma, and more, this new book offers a blend of new technologies and new insights in the fields of both pigmentation and mouse genetics. It includes some comparative information on other organisms as well. Inhaltsverzeichnis Preface vii Acknowledgments ix Statement regarding the use of pictures x Statement regarding nomenclature xii PART I INTRODUCTION TO THE PIGMENTARY SYSTEM 1 1 Introduction to the Pigmentary System 3 1.1 Introduction 3 1.2 Colors of vertebrate animals 4 1.3 Other pigment cells 12 1.4 The epidermal melanin unit 12 1.5 Mammalian hair 13 1.6 Melanosome biogenesis and translocation 14 1.7 Melanin 15 1.8 Hair growth 15 1.9 Hair growth cycles 17 1.10 Embryonic development of the pigment cell lineage 18 1.11 Pigment cells in culture 18 1.12 Conclusion 19 Appendix: color loci of the mouse 20 PART II THE PIGMENTARY LOCI 49 2 Introduction to Mutant Pigmentary Genes 51 2.1 Defects of normal melanocyte development: white spotting and graying with age 51 2.2 Defects in normal melanosome development: albinism 52 2.3 Transport of melanosomes to other cells: the 'dilute' phenotype 53 2.4 Pigment-type switching: from eumelanogenesis to pheomelanogenesis 54 3 White Spotting and Progressive Graying 57 3.1 Definitions and general background 58 3.2 Pigment-cell development: developmental biology 62 3.3 Cellular signaling pathways for melanocytes 71 3.4 Pigment phenotypes and the classical white-spotting genes 88 3.5 The head, heart, ears, and eyes 127 4 'Albinism' and the Failure of Normal Melanosome Development 132 4.1 Background 133 4.2 The melanosomal matrix 140 4.3 The enzymes that catalyze melanogenesis 146 4.4 Membrane proteins that regulate the internal milieu of the melanosome 153 4.5 Protein processing and routing to the maturing melanosome 156 4.6 Melanosome transport 171 5 Pigment-Type Switching 177 5.1 Introduction 178 5.2 Yellow phenotypes 184 5.3 Melanin pigment 189 5.4 Melanogenesis and the eumelanin/pheomelanin switch mechanism 190 5.5 Signaling the switch mechanism at the cellular level 192 5.6 Yellow genes 194 PART III TECHNOLOGY AND RESOURCES 207 6 Novel Mouse Pigmentary Mutants Generated by Genetic Manipulation 209 6.1 ...
