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Informationen zum Autor Syed F. Ali is the editor of Drug Addiction: Research Frontiers and Treatment Advances, Volume 1120, published by Wiley. Michael J. Kuhar, a neuroscientist, professor, and author, is currently Candler Professor of Neuropharmacology at The Yerkes National Primate Research Center of Emory University. Kuhar is also a Georgia Research Alliance Eminent Scholar, and a Senior Fellow in the Center for Ethics at Emory. Klappentext This volume brings together basic and clinical science to provide in-depth understanding and current knowledge concerning new conceptual insights into the CNS acting drugs and drugs of abuse and treatment of drug addiction.Methamphetamine, MDMA, PMA and different solvents are the most widely abused drugs in the Europe, United States, Central America, South America and Asian Countries and their use has dramatically increased over the last two decades. These drugs of abuse are known to cause neurotoxicity in several species including not only rodents, dogs and nonhuman primates, but also humans. However, precise neurochemical mechanisms underlying this drug-induced neurotoxicity remain unclear.This volume addresses the following:1) Role of Genomics, Proteomics and Metabonomics in Drug-induced Neurotoxicity2) Drugs of Abuse and Medication Development3) Molecular Biology and Free Radicals in Drugs of Abuse-induced neurotoxicity4) Substituted Amphetamines-induced Neurochemical Changes and Relationship to Neurotoxicity5) Drug of Abuse and Imaging Brain Structure and Function6) GHB/Volatile Solvent/Inhalant NeurotoxicityNOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member. Zusammenfassung This volume presents new conceptual insights into the mechanisms of CNS-acting drugs and drugs of abuse as well as treatment of drug addiction. Methamphetamine, MDMA, PMA and different solvents are the most widely abused drugs and their use has dramatically increased over the last two decades. Inhaltsverzeichnis Part I: Gene Regulation and Drug Abuse:. 1. c-Fos Is an Intracellular Regulator of Cocaine-induced Long-term Changes: Ming Xu. 2. The Expression of NMDA Receptor Subunit mRNA in Human Chronic Alcoholics: Influence of Cirrhosis and Genotype: Justin P. Ridge, Ada M.-C. Ho, David J.Innes, and Peter R. Dodd. 3. Dopamine Receptor d4 Gene -521c/t polymorphism Is Associated with Opioid Dependence through Cold-Pain Responses: Ada M.-C. Ho, Nelson L.-S.Tang, Ben K.-L. Cheung, and Alfreda. Stadlin. 4. Injection of the Neuropeptide CNP into Dopaminergic Rat Brain Areas Decreases Alcohol Intake: Pascal Romieu, Serge Gobaille, Dominique Aunis, and Jean Zwiller. 5. Transcriptional Correlates of Human Substance Use: Elin Lehrmann and William J. Freed. 6. Association Study between Casein Kinase 1 Epsilon Gene and Methamphetamine Dependence: T. Kotaka, H. Ujike, Y. Morita, M. Kishimoto, Y. Okahisa, T. Inada, M. Harano, T. Komiyama, T. Hori, M. Yamada, Y. Sekine, N. Iwata, M. Iyo, I. Sora, N. Ozaki, and S. Kuroda. 7. Short Allele of 5-HTTLPR As a Risk Factor for the Development of Psychosis in Japanese Methamphetamine Abusers: Norikazu Ezaki, Kazuhiko Nakamura, Yoshimoto Sekine, Ismail Thanseem, Ayyappan Anitha, Yasuhide Iwata, Masayoshi Kawai, Kiyokazu Takebayashi, Katsuaki Suzuki, Nori Takei, Masaomi Iyo, Toshiya Inada, Nakao Iwata, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Hiroshi Ujike, and Norio Mori. 8. Association Study of the Calc...
