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Informationen zum Autor Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School. Klappentext Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research. * Contributions from leading authorities and industry experts * Informs and updates on all the latest developments in the field Zusammenfassung Presents developments as well as comprehensive reviews in immunology. This work addresses the range of topics that comprise immunology! including molecular and cellular activation mechanisms! phylogeny and molecular evolution! and clinical modalities. Inhaltsverzeichnis 1. TSLP in Epithelial cell and Dendritic Cell Cross Talk Yong-Jun Liu 2. Natural Killer Cell Tolerance: Licensing and Other Mechanisms A. Helena Jonsson and Wayne M. Yokoyama 3. Biology of the Eosinophil Carine Blanchard and Marc E. Rothenberg 4. Basophils: Beyond Effector Cells of Allergic Inflammation John T. Schroeder 5. AID DNA targets Ali A. Zarrin, Jason Hackney, Kate Senger, Christopher Garris, Yonglian Sun, Maria N. Lorenzo, and Shahram Misaghi...
Sommario
1. TSLP in Epithelial cell and Dendritic Cell Cross Talk
Yong-Jun Liu
2. Natural Killer Cell Tolerance: Licensing and Other Mechanisms
A. Helena Jonsson and Wayne M. Yokoyama
3. Biology of the Eosinophil
Carine Blanchard and Marc E. Rothenberg
4. Basophils: Beyond Effector Cells of Allergic Inflammation
John T. Schroeder
5. AID DNA targets
Ali A. Zarrin, Jason Hackney, Kate Senger, Christopher Garris, Yonglian Sun, Maria N. Lorenzo, and Shahram Misaghi
Relazione
"The series which all immunologists need." --THE PHARMACEUTICAL JOURNAL
"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --SCIENCE
"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --JOURNAL OF IMMUNOLOGICAL METHODS
