Ulteriori informazioni
Informationen zum Autor Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School. Klappentext Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Zusammenfassung Presents developments as well as comprehensive reviews in immunology. This book includes articles which addresses the wide range of topics that comprise immunology! including molecular and cellular activation mechanisms! phylogeny and molecular evolution! and clinical modalities. Inhaltsverzeichnis 1. Cis-Regulatory Elements and Epigenetic Changes Control Genomic Rearrangements of the IgH Locus Thomas Perlot and Frederick W. Alt 2. DNA-PK: The means to justify the ends? Katheryn Meek, Van Dang, and Susan P. Lees-Miller 3. Thymocyte selection including the new proteosome system Yousuke Takahama 4. Myocarditis Noel R. Rose 5. IL-17 Casey Weaver 6. TSLP and determinants of a Th2 host response Yong-Jun Liu...
Sommario
1. Cis-Regulatory Elements and Epigenetic Changes Control Genomic Rearrangements of the IgH Locus
Thomas Perlot and Frederick W. Alt
2. DNA-PK: The means to justify the ends?
Katheryn Meek, Van Dang, and Susan P. Lees-Miller
3. Thymocyte selection including the new proteosome system
Yousuke Takahama
4. Myocarditis
Noel R. Rose
5. IL-17
Casey Weaver
6. TSLP and determinants of a Th2 host response
Yong-Jun Liu
Relazione
"The series which all immunologists need." --THE PHARMACEUTICAL JOURNAL
"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --SCIENCE
"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --JOURNAL OF IMMUNOLOGICAL METHODS
