Sparking Signals - Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation

Protein phosphorylation is an essential post-translational modification that modulates cell-cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups.

Sommario

Proteomics-bases Strategies in Kinase Drug Discovery.- PKC Isotype Functions in T-Lymphocytes.- Molecular and Systems-Biology Approaches to Define Signaling Pathways in Lymphocytes.- Solving the IRAK-4 Enigma. Application of Kinase-Dead Knock-In Mice.- Sensing, Presenting and Regulating PAMPS.- Migration, Cell-Cell Interaction and Adhesion in the Immune System.- The Role of Diacylglycerol Kinases in T Cell Anergy.- Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts.- Fragment-Based Drug Discovery Using Rational Design.

Riassunto

Protein phosphorylation is an essential post-translational modification that modulates cell–cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups.

Dettagli sul prodotto

• Con la collaborazione di: Gottfried Baier (Editore), Arne Bonin (Editore), Arne von Bonin (Editore), Burkhar Schraven (Editore), Burkhart Schraven (Editore), Arne von Bonin (Editore), Ulrich Zügel (Editore), Ulrich Zügel et al (Editore)
• Editore: Springer, Berlin
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 14.04.2009
• EAN: 9783540735007
• ISBN: 978-3-540-73500-7
• Pagine: 187
• Dimensioni: 147 mm x 14 mm x 216 mm
• Illustrazioni: XIV, 187 p.
• Serie: Ernst Schering Research Foundation Workshop; Ernst Schering Foundation Symposium Proceedings; Ernst Schering Foundation Symposium Proceedings
• Categorie: Scienze naturali, medicina, informatica, tecnica > Medicina > Farmacia; Biochemie, C, Immunologie, Immunology, Life Sciences, biochemistry, Pharmacology, Biomedical and Life Sciences, Biochemistry, general, Pharmacology/Toxicology