Nucleic Acids in Innate Immunity

Informationen zum Autor Ken J. Ishii! Shizuo Akira Klappentext Recent research has shown that by binding to toll-like receptors! nucleic acids can modulate the innate immune response. While most of the bound nucleic acids are derived from microorganisms! some can be derived from the host! resulting in autoimmune disease. Written by international leading experts! Nucleic Acids in Innate Immunity provides an in-depth description of the role of nucleic acids in immunity. This book presents various mechanisms and therapeutic applications of immunomodulatory DNA as well as the structure and function of toll-like receptors. The text also discusses how the immune system discriminates self and non-self DNA and RNA and details the recognition of small interfering RNA. Zusammenfassung Explaining the roles of nucleic acids in immunity, this book describes the mechanism of discrimination based on pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLR), and RIG-I-like receptors (RLR). It reveals different directions for the research in immune modulation. Inhaltsverzeichnis Role of Nucleic Acids in Immunity. Mechanisms and Therapeutic Applications of Immunomodulatory DNA. How Do We Discriminate Self and Non-Self RNA?

Dettagli sul prodotto

• Autori: Ken J. (Osaka University Ishii, Ken J. Akira Ishii
• Con la collaborazione di: Shizuo Akira (Editore), Shizuo (Osaka University Akira (Editore), Akira Shizuo (Editore), Ken J. Ishii (Editore), Ken J. (Osaka University Ishii (Editore), Ishii Ken J. (Editore)
• Editore: Taylor & Francis Ltd.
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 22.05.2008
• EAN: 9781420068252
• ISBN: 978-1-4200-6825-2
• Pagine: 302
• Categorie: Scienze naturali, medicina, informatica, tecnica > Medicina > Branche cliniche; Immunology, MEDICAL / General, MEDICAL / Immunology, SCIENCE / Life Sciences / Cell Biology, MEDICAL / Infectious Diseases, Infectious & contagious diseases, Cellular biology (cytology), Infectious and contagious diseases