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Grauzone and Completion of Meiosis During Drosophila Oogenesis describes the work behind a major, award winning discovery: the establishment of a new pathway that specifically regulates the female meiosis, a process essential for sexual reproduction. This book chronicles a new gene mapping method and the cloning and documentation of several types of genes that were proven to have significant influence on the cell cycle. It is of interest to anyone doing work with fruit flies, both graduate students and principal investigators.
Sommario
General introduction.- 1. Female meiotic cell cycle.- 2. Genesis and meiosis in drosophila females.- 3. Cell cycle regulation of Drosophila female meiosis.- 4. Mutations in grauzone (grau) and cortex(cort) block progression of drosophila female meiosis and cause other defects.- 5. Goals and significance of this dissertation research.- Mapping of drosophila mutations using site-specific male recombination.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Discussion.- Completion of meiosis in drosophila oocytes requires transcriptional control by grauzone, a new zinc finger protein.- 1. Introduction.- 2. Experimental Procedures.- 3. Results.- 4. Discussion.- 5. Acknowledgements.- Conclusions and Considerations.- 1. Drosophila as a model to study regulation of female meiotic cell cycle.- 2. Grau and cort are two members of a new pathway that regulates the meiotic cell cycle machinery in drosophila females.- 3. Male recombination mapping is a general method to map drosophila autosomal mutations.- References.
Info autore
Bin Chen
is a researcher at Stanford University and is the winner of the Larry Sandler Award.
Riassunto
Grauzone and Completion of Meiosis During Drosophila Oogenesis
describes the work behind a major, award winning discovery: the establishment of a new pathway that specifically regulates the female meiosis, a process essential for sexual reproduction. This book chronicles a new gene mapping method and the cloning and documentation of several types of genes that were proven to have significant influence on the cell cycle. It is of interest to anyone doing work with fruit flies, both graduate students and principal investigators.
