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Actin is a ubiquitous protein present in high concentrations in virtually all cells. It's assembly and disassembly is modulated by more than 100 actin-binding proteins. These interactions are essential for a variety of important cellular processes including cell division, gene expression and motility.
There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders.
This volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole. Additionally, clinicians will be interested because the book explains the role of cytoskeletal proteins in various diseases, including cancer and immune system disorders.
Sommario
Actin.- Actin: An Overview of Its Structure and Function.- Actin Genetic Diseases.- Actin-Binding Drugs: An Elegant Tool to Dissect Subcellular Processes in Endothelial and Cancer Cells.- Autoantigenicity of Actin.- Actin-Binding Proteins.- Overview: Actin-Binding Protein Function and Its Relation to Disease Pathology.- ADF/Cofilin, Actin Dynamics, and Disease.- Gelsolin and Disease.- Profilin.- The Roles of Thymosin ?4 in Cell Migration and Cell-to-Cell Signaling in Disease.- Actin-Binding Proteins.- Actin and Actin-Binding Proteins in Cancer Progression and Metastasis.- Diseases with Abnormal Actin and Actin-Binding Proteins in Leukocyte and Nonmuscle Cells.- The Role of PIP2 in Actin, Actin-Binding Proteins and Disease.- Intracellular Pathogens and the Actin Cytoskeleton.- Actin and Its Binding Proteins in Heart Failure.
Riassunto
Actin is a ubiquitous protein present in high concentrations in virtually all cells. It's assembly and disassembly is modulated by more than 100 actin-binding proteins. These interactions are essential for a variety of important cellular processes including cell division, gene expression and motility.
There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders.
This volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole. Additionally, clinicians will be interested because the book explains the role of cytoskeletal proteins in various diseases, including cancer and immune system disorders.
