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Regenerative medicine aims to cure chronic intractable diseases by replacing malfunctioning cells and tissues with healthy ones and enhancing their repair and regeneration. Over the past decade, there has been exponential reporting of new technologies that advanced translational and clinical research in this field. Regenerative medicine applications have thus evolved to include tissue engineering and bioprinting in addition to cell therapy and gene therapy. Importantly, new technologies in regenerative medicine are increasingly moving to replace organ and tissue transplantation with cellular therapies and the use of extracellular vesicles (EVs). The latter are characterized as important vectors and therapeutic targets in many diseases such as cancer, neurodegenerative diseases, cardiovascular diseases, and inflammation. The book chapters cover new technologies and advances in regenerative medicine to treat chronic diseases, including cancer, diabetes, musculoskeletal diseases, dental diseases, and others.
Sommario
Chapter 1. Microbial Mediators: Unraveling the Interplay between Microbes and Mesenchymal Stem Cells in Transplantation Dynamics.- Chapter 2. Applications of Stem Cell Therapy in Cardiovascular Disease.- Chapter 3. Extracellular Vesicles in Neurodegenerative Diseases: Tools for Therapy and Regeneration.- Chapter 4. Organoids as an Innovative Model for Tumor and Immune Cell Interactions: Implication for Immunotherapy.- Chapter 5. The Application of Stem Cells in Chronic Wound Healing.- Chapter 6. Cell Therapy for Type 1 Diabetes Mellitus.- Chapter 7. Regenerative Medicine in Acute and Chronic Lung Disease.- Chapter 8. Metabolic Mayhem in the Tumor Microenvironment: Can Mesenchymal Stromal Cells Restore Order?.- Chapter 9. Emerging Regenerative Therapies for Solid Tumors: Epigenetics and Epitranscriptomics Crosstalk.- Chapter 10. Regenerative Medicine for Muscle Disorders: Advances and Challenges Ahead.- Chapter 11. The Theragnostic Role of Mesenchymal Stem Cells - Derived Extracellular Vesicles in Hepatocellular Carcinoma Management.- Chapter 12. Phenotypic Signature of Leukemic Stem Cells and Their Signaling Pathways for Potential Targeting Strategies.
