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Reactive oxygen species (ROS)-mediated inflammation plays a critical role in the onset and progression of various metabolic disorders, including obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD). Dysregulated ROS production leads to oxidative stress, which triggers chronic low-grade inflammation, disrupting cellular homeostasis and metabolic functions. This pathological interplay exacerbates insulin resistance, lipid accumulation, and mitochondrial dysfunction, creating a vicious cycle of metabolic dysregulation. Understanding the molecular mechanisms behind ROS-mediated inflammation is crucial for developing targeted therapeutic interventions to break this cycle and mitigate disease progression.
This comprehensive book bridges the gap between fundamental molecular insights and translational therapeutic strategies. It begins by delving into the signaling pathways involved, such as NF-κB and Nrf2, and highlighting the role of key players like mitochondria and antioxidant systems. Later chapters explore emerging therapeutic approaches, including postbiotics, natural antioxidants, and pharmacological agents, offering practical solutions for managing metabolic disorders. By addressing this critical intersection of inflammation, oxidative stress, and metabolism, this book is a valuable guide for researchers, clinicians, and healthcare professionals who aim to tackle the global burden of metabolic diseases effectively.
Sommario
1. Introduction to Metabolic Disorders.- 2. Introduction to ROS and Inflammation.- 3. Enzymatic and non-enzymatic mechanisms of ROS generation in Metabolic Disorders.- 4. ROS‐mediated cellular signaling in Metabolic Disorders.- 5. Epigenetic Regulation of Oxygenases involved in ROS production in Metabolic Disorders.- 6. Interplay between ROS and Inflammation in alcoholic fatty liver disease.- 7. ROS and Eicosanoid mediated inflammation in Metabolic Disorders.- 8. Cellular cytokine storm mediated Inflammation in Metabolic Disorders.- 9. Eicosanoids and Bioactive Lipids in Modulation of Inflammation in Metabolic Disorders.- 10. ROS and Inflammation Interplay in Hypertension and other CVDs.- 11. Interplay of ROS and Inflammatory Pathways in Diabetes.- 12. Connection between Thyroid Hormones and ROS mediated inflammation in Hyperthyroidism.- 13. ROS: Mediated inflammation in Cancer cell & tumour microenvironment.- 14. ROS: Pathogenesis & progression in Obesity.- 15. ROS and Inflammation in Mitochondrial Disorders.- 16. ROS and Ferroptosis impact on Inflammation mediated Haemochromatosis.- 17. Nanomedicine-Driven Dual Delivery of ROS Scavengers and Anti-Inflammatory Agents in Metabolic Disorders.- 18. Role of Iron in Metabolic disorders via ROS Influence on Inflammation.- 19. Dietary and Lifestyle Interventions in ROS-Mediated Metabolic Disorders.- 20. Role of Pro, Pre and postbiotics targeting gut-microbiota for ROS inhibition.- 21. Artificial intelligence, deep learning and machine learning to target ROS mediated inflammation inhibition in Metabolic Disorders.- 22. Nanocarrier based Targeted approaches: To scavenge ROS mediated inflammation.- 23. Complementary and alternative medicine (CAM) therapy to inhibit ROS mediated inflammatory disorders.- 24. Clinical Perspectives on ROS-Mediated Inflammation in Metabolic Disorders: Clinical and preclinical study, models etc.- 25. Challenges and Opportunities in Translating ROS Research into Clinical Applications.
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Sumel Ashique has been working as an assistant professor at Department of Pharmaceutical Technology, Bharat Technology, Uluberia-711316, West Bengal, India. He has knowledge in drug delivery, nanotechnology and targeted treatment strategy. Currently he has edited 18+ books under CRC Press, Taylor and Francis, Wiley, Nova Science and Springer. Recently, honored to be in World Top 2% Scientists by prestigious Stanford University, CA, USA and Elsevier in 2025.
Dr. Neeraj Mishra is working as Professor in Amity Institute of Pharmacy, Gwalior since July 2019. He has around twenty years of teaching and research experience. He has more than 150 publications of International and National repute in recent concepts of novel drug delivery systems, localized drug delivery, targeted and controlled drug delivery etc. He has also written 25 Books and 45 book chapters in Elsevier, Bentham, Springer and Wiley Publication etc. Recently, honored to be in World Top 2% Scientists by prestigious Stanford University, CA, USA and Elsevier in 2025.
