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Parasitic protozoa, including some which are agents of human and veterinary diseases, display special cytoplasmic structures and organelles. Metabolic pathways have been discovered in these organelles which open up new possibilities for drug targets.
This work presents reviews dealing with cytoskeletal structures such as the mastigont system found in trichomonads, the sub-pellicular microtubules in trypanosomatids and the paraflagellar rod. Further chapters cover structures involved in the synthesis, secretion and uptake of molecules, including the flagellar pocket of trypanosomatids, the reservosome of Trypanosoma and the megasome found in Leishmania, the traffic of vesicles in Entamoeba histolytica, secretory organelles and the secretory events of intestinal parasites during encystation. Reviews on special organelles, such as the kinetoplast-mitochondrion complex, the apicoplast found in Apicomplexa, the glycosomes in Kinetoplastida and the acidocalcisomes found in several protozoa complete the volume.
Sommario
Marlene Benchimol: The Mastigont System in Trichomonads; Wanderley de Souza and Marcia Attias: Subpellicular Microtubules Subpellicular Microtubules in Apicomplexa and Trypanosomatids; Johanna Buisson and Philippe Bastin: Flagellum structure and function in trypanosomes; Paul G McKean and Keith Gull: The flagellar pocket of trypanosomatids: a critical feature for cell morphogenesis and pathogenicity; Narcisa Leal Cunha e Silva, Celso Sant Anna, Miria G. Pereira and Wanderley de Souza: Reservosomes of Trypanosoma cruzi; Diane McMahon-Pratt, Tania Ueda-Nakmura e Yara Traub-Cseko: Megasomes in Leishmania; Sherri Smith e Nancy Guillen: Organelles and Trafficking in Entamoeba histolytica; Jean François Dubremetz: Secretory organelles in Apicomplexa; Fernando Rivero, Muller Dana e Lujan Hugo: Secretory events during Giardia encystations; Julius Lukes, Hashimi Hassan, Verner e Zdenek Cicová Zdenka: The remarkable mitochondrion of trypanosomes and related flagellates; Swaiti Agrawal, Nair Sethu, Sheiner Lilach e Boris Striepen: The Apicoplast: An ancient algal endosymbiont of Apicomplexa; Fred Opperdoes: The Glycosome of Trypanosomatids; Paul Ulrich, Cintrón Rozana-Moret e Roberto Docampo: Calcium Homeostasis and Acidocalcisomes in Trypanosoma cruzi.
