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Rodent Models of Neurodegenerative Diseases explores neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, Frontotemporal dementia, Lewy body disease, and Prion disease which represent some of the most complex and devastating challenges in neuroscience. With rising prevalence in aging populations worldwide, these disorders place immense burdens on patients, families, and healthcare systems. This comprehensive volume
, Rodent Models of Neurodegenerative Diseases, provides an in-depth examination of the utility, strengths, and limitations of rodent models in unraveling the molecular, cellular, and behavioral aspects of neurodegeneration. Organized by disease, each chapter explores both genetic and non-genetic models, highlighting their relevance to human pathology, translational value, and contributions to therapeutic discovery.
Sommario
1 Introduction to Animal Models in Neurodegenerative Research: bridging the gap between Lab and Clinic
2 Rodent models of NDGS: expoloring the depths of the brain
3 Modeling Alzheimer's disease (AD) in rodents
4 Modeling Parkinson's disease (PD) in rodents
5 Modeling Huntington's Disease (HD) in rodents
6 Modeling Amyotrophic Lateral Sclerosis (ALS
7 Modeling Frontotemporal Dementia (FTD)
8 Modeling Prion Diseases
9 Modeling Lewy Bodies
10 Rodents on the frontline; impactful insights into NDGs
Info autore
Dr. Rasoul Ghasemi, PhD, is an Associate Professor of Physiology in the Department of Physiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. His research explores the neurophysiology of learning and memory, with emphasis on insulin signaling, hippocampal function, neuroinflammation, oxidative stress, and neuroprotection in neurodegenerative diseases. He has published extensively on the cellular and molecular mechanisms underlying brain resilience and pathology. Dr. Pegah Javadpour, PhD, is an Assistant Professor of Medical Physiology at the Neuroscience Research Center, Institute of Neuroscience and Cognition, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Her research focuses on mitochondrial dysfunction, oxidative stress, and neuroinflammation in neurodegenerative disorders, particularly Parkinson's and Alzheimer's disease. She has a special interest in mitochondria-targeted therapeutic strategies, including mitochondrial transplantation therapy (mitotherapy), as potential treatments for these conditions. Sahar Askari (PhD) has a PhD in medical physiology from Iran with thesis title: Behavioral and molecular effects of Thapsigargin (ER stress inducer) on the memory impairment (in-vivo) with the considering MAPKs (JNK, ERK, P38), IRS-1 and apoptosis pathways, and the role of the time in ER stress performance and related molecules (in-vitro (cell culture). She published few papers on animal models, surgeries, and in vivo modelling of NDG disorders.
