Handbook of Synthetic Biology

This reference work presents a comprehensive and authoritative overview of the rapidly evolving field of synthetic biology. It brings together the foundational concepts, technological innovations, and wide-ranging applications that define this discipline. By applying engineering principles to biological systems, synthetic biology enables the design of novel biological parts, systems, and functions. The handbook explores recent breakthroughs ranging from synthetic circuits for diagnostics and therapeutics to engineered biomaterials and biofuels, positioning itself as a valuable, one-stop reference for this interdisciplinary science. Synthetic biology has grown into a transformative field at the intersection of biology, engineering, and computation. It allows precise control and design of biological systems through synthetic promoters, ribosome binding sites, genetic circuits, and other engineered components. These capabilities are driving innovations in health, environment, and energy. The handbook is organized into five sections. These cover: fundamentals of synthetic biology; advances in tools and methodologies; real-world applications across diagnostics, therapy, and biotechnology; synthetic biology s role in treating human diseases; and finally, ethical, regulatory, and societal considerations. Each chapter provides accessible, well-structured insights for readers across disciplines. This handbook is designed for a diverse audience including researchers, students, clinicians, industry experts, and policymakers. It serves as both an introductory guide and a detailed reference, offering rich, easy-to-understand content enhanced by clarity, depth, and broad coverage. This is a foundational resource for anyone looking to engage with the future of biology.

Sommario

Section I: Fundamental of synthetic biology.- Overview of synthetic biology.- Computational tools in synthetic biology.- Design and Characterization of genetic parts in Synthetic biology.- Standardization and modularity of synthetic biology.- Design and characterization of synthetic oscillators.- Section II: Advances in synthetic biology.- Design and characterization of the synthetic microbial genome.- Expansion of genetic codes and its applications.- Xeno nucleic acids and their applications.- Minimal cells.- Synthetic cells.- Cell free systems: Applications.- Gene and Genome Assembly.- De novo gene Synthesis.- Section III: Applications of synthetic biology.- Synthetic biology-based diagnostic tools.- Synthetic biology-based biosensors.- RNA-based Therapeutics.- RNA-based Vaccines.- Cell based therapy.- Section IV: Synthetic biology for human disease.- Design of chimeric antigen receptor-T therapy.- Synthetic biology for treatment of cancer.- Synthetic biology for treatment of blood disorders.- Section V: Synthetic biology ethics and regulations.- Synthetic biology for biosafety and ethics.- Synthetic biology patents and technology.- Impact of synthetic biology on society.- Regulatory aspects of synthetic biology.- Economic aspects of synthetic biology.

Info autore

Dr. Vijai Singh is a Professor and Head of the Department of Biosciences, School of Science at Indrashil University, Rajpur, Mehsana, India. He has worked as Associate Professor in the Department of Biosciences, School of Science at Indrashil University, Rajpur, Mehsana, India. He was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology (2009) from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 12 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 105 articles, 74 book chapters, 25 books and 3 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.

Riassunto

This reference work presents a comprehensive and authoritative overview of the rapidly evolving field of synthetic biology. It brings together the foundational concepts, technological innovations, and wide-ranging applications that define this discipline. By applying engineering principles to biological systems, synthetic biology enables the design of novel biological parts, systems, and functions. The handbook explores recent breakthroughs ranging from synthetic circuits for diagnostics and therapeutics to engineered biomaterials and biofuels, positioning itself as a valuable, one-stop reference for this interdisciplinary science.
 
Synthetic biology has grown into a transformative field at the intersection of biology, engineering, and computation. It allows precise control and design of biological systems through synthetic promoters, ribosome binding sites, genetic circuits, and other engineered components. These capabilities are driving innovations in health, environment, and energy.
 
The handbook is organized into five sections. These cover: fundamentals of synthetic biology; advances in tools and methodologies; real-world applications across diagnostics, therapy, and biotechnology; synthetic biology’s role in treating human diseases; and finally, ethical, regulatory, and societal considerations. Each chapter provides accessible, well-structured insights for readers across disciplines.
 
This handbook is designed for a diverse audience—including researchers, students, clinicians, industry experts, and policymakers. It serves as both an introductory guide and a detailed reference, offering rich, easy-to-understand content enhanced by clarity, depth, and broad coverage. This is a foundational resource for anyone looking to engage with the future of biology.

Dettagli sul prodotto

• Con la collaborazione di: Vijai Singh (Editore)
• Editore: Springer, Berlin
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 14.07.2026
• EAN: 9789819539567
• ISBN: 978-981-9539-56-7
• Pagine: 1270
• Illustrazioni: XX, 1180 p. 160 illus., 110 illus. in color.
• Categorie: Scienze naturali, medicina, informatica, tecnica > Biologia > Biochimica, biofisica; Krankheiten und Störungen, Genetik (nicht-medizinisch), Wissenschaftliche Ausstattung, Experimente und Techniken, Diseases, Synthetic Biology, Genetic Techniques, Synthetic gene networks, State-of-the-art in synthetic biology, Synthetic biology approaches for human disease, Synthetic biology in drug design