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This book, the proceedings of the 32nd International Conference on Transplantation and Clinical Immunology, held in Lyon, France, on May 25-26, 2000, addresses novel issues in terms of changing indications for transplantation in the management of organ failure, whether humans will remain the only source for organ procurement, prospects for engineering in organ replacement, and whether transplantation will remain the most appropriate approach to organ failure. Some promising treatments are approached, such as enzymic and biochemical replacement, gene therapy, tolerance induction, stem cell transplantation, and xenotransplantation. In addition to the constant improvement in conservative management of organ failure in general, ongoing research in selected fields is reported in the proceedings, such as liver transplantation vs artificial liver, novel dialysis strategies vs evolving immunosuppression in kidney transplantation, islets transplantation and external implantable insulin pumps vs pancreas transplantation in diabetic patients, circulatory assistance and intramyocardial myoblast injection vs heart transplantation. Pivotal experience in selected emerging transplantations is included, that is, small bowel, limb, skin and neuronal transplantation. Such fascinating perspectives raise medical, economical, and ethical problems which are discussed in this book.
Sommario
Past and Future Alternatives and Strategies. Trends in the epidemiology of end-stage renal disease over the last decade; P. Landais. Answers to liver graft shortage: hepatocyte transplantation and bioartificial liver; Y. Calmus. Enzymatic and biochemical substitutes to organ transplantation in inborn errors of metabolism; P. Cochat. Tolerance induction; K.J. Wood. Xenotransplantation: immunological advances; G. Blancho. Liver Replacement Therapy. Living donor in liver transplantation as novel graft source; O. Boillot. Ex-situ liver support; I. Méchet. Renal Replacement Therapy. Preventing end-stage renal disease: fact or fiction? B. Kasiske. Transplantation and short daily hemodialysis; J. Traeger. Comparison of survival probabilities between renal transplant recipients and patients undergoing regular dialysis: a single center prospective study; G. Segoloni. Transplantation versus dialysis in aged and type 2 diabetic patients; C. Pouteil-Noble. Pancreas Replacement Therapy. External and implantable insulin pumps: current place in the treatment of diabetes; J.L. Selam. Pancreas and islet transplantation in the treatment of type 1 diabetes; X. Martin. Perspectives in early detection and management of IDDM; C. Thivolet. Heart and Lung Replacement Therapy. Mechanical circulatory support: today's fact and future horizons; A. El-Banayosys. Intra-myocardial myoblast injection; P. Ménasché. Ambulatory management of primary pulmonary hypertension; J.L. Vachiéry. Cystic fibrosis: conservative management; A. Clément. Emerging Transplantations and Management. Intestinal transplantation; O. Goulet. Intracerebral grafting of fetal neuroblasts for neurodegenerative diseases: experimental bases and clinical results; M. Pechansky. Skin equivalents; O. Damour. Concluding Remarks. Public health issues from European countries; M. Manyalich. Clinical evaluation of organ transplantation in France; Y. Matillon. From Lyon to Louisville: the need for tolerance; L. Ross.
Riassunto
This text addresses issues in the management of organ failure, whether humans will remain the only source for organ procurement, prospects for engineering in organ replacement, and whether transplantation will remain the most appropriate approach to organ failure.
