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Informationen zum Autor Professor Thinus F. Kruger MD FRCOG - Reproductive Biology Unit, Department of Obstetrics & Gynaecology, Tygerberg Hospital, Tygerberg, South Africa Professor Sergio Oehninger - Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, VA, USA Klappentext Male factor infertility is a common problem in reproductive medicine and can have a significant effect of the outcome of IVF treatment. This comprehensive book covers the diagnosis and treatment of male factor infertility in depth. It opens with a section on the basic science underlying the production of male gametes. There is then a major section on diagnosis that will prove very useful to a wide range of andrologists! endocrinologists! and REIs faced with unpicking the problems facing infertile couples. The final section addresses management of the subfertile male! including endocrinologic! surgical! and ART interventions. The book is authored by a prestigious! international team of contributors. Zusammenfassung Male factor infertility is a common problem in reproductive medicine and can have a significant effect of the outcome of IVF treatment Inhaltsverzeichnis SECTION 1: BASIC CONCEPTS: SPERM PHYSIOLOGY AND PATHOLOGY 1. Functional anatomy and molecular morphology of the spermatozoon 2. Physiology and pathophysiology of sperm motility 3. The pathophysiology and genetics of human male reproduction 4. Contribution of the male gamete to fertilization and embryogenesis 5. Genome architecture in human sperm cells: possible implications for male infertility and prediction of pregnancy outcome 6. Sperm pathology: pathogenic mechanisms and fertility potential in assisted reproduction 7. Testicular dysgenesis syndrome (TDS): biological and clinical significance SECTION 2: DIAGNOSIS OF MALE INFERTILITY 8. Evaluation of the subfertile male 9. The basic semen analysis 10. Advances in automated sperm morphology evaluation 11. Sperm morphology training and quality control programs are essential for clinically relevant results 12. The role of the acrosome index in prediction of fertilization outcome 13. Acrosome reaction: physiology and its value in clinical practice 14. Sperm-zona pellucida binding assays 15. Detection of DNA damage in sperm 16. Chromosomal and genetic abnormalities in male fertility 17. Reactive oxygen species and its impact on fertility 18. How do we define male subfertility and what is the prevalence in the general population? 19. DNA fragmentation and its influence on fertilization and pregnancy outcome 20. The impact of the paternal factor on embryo quality and development: the embryologist’s point of view SECTION 3: THERAPEUTIC ALTERNATIVES FOR MALE INFERTILITY 21. Clinical management of male infertility 22. Urological interventions for the treatment of male infertility 23. Medical treatment of male infertility 24. Male tract infections: diagnosis and treatment 25. Sperm-washing techniques for the HIV-infected male: rationale and experience 26. Treatment of HIV discordant couples – the Italian experience 27. Artificial insemination using homologous and donor semen 28. Intracytoplasmic sperm injection: current status of the technique and outcome 29. Sperm retrieval for intracytoplasmic sperm injection 30. Hyaluronic acid binding by human sperm: andrology evaluation of male fertility and sperm selection for intracytoplasmic sperm injection 31. In-vitro maturation of spermatozoa 32. New developments in the evaluation and management of the infertile male ...
