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Research on, and interest in, red blood cell formation spans several centuries and was thought to have peaked in the 1980s with the cloning of the eryth- poietin (EPO) gene. In the years subsequent to the cloning of EPO and its expression as a recombinant protein, much was written about EPO. Although much has been learned and published, new, exciting data are becoming ava- able on almost a daily basis. Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology compiles both pertinent historical and very recent research on this molecule and its clinical utility. The book is divided into two sections: Background and Basic Science and Clinical Uses of Recombinant Erythropoietins. To begin, Israels and Israels describe the biology of red cells, the hierarchy of erythropoietic progenitor cells, their development to mature cells, and the effects of endogenous EPO on their development. Foote summarizes the historical interest in, and search for, an erythropoietic factor. Once EPO was identified, cloned, and expressed, the path was set for the study of other aspects of EPO biology both within e- thropoiesis and other cellular systems.
Sommario
Background.- Erythropoiesis: an overview.- Regulation of endogenous erythropoietin production.- Biology of erythropoietin.- Erythropoiesis-genetic abnormalities.- Erythropoiesis-stimulating agents.- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin.- Commercial production of recombinant erythropoietins.- Biosimilar epoetins.- New molecules and formulations.- Erythropoietin receptor.- Structural basis for the signal transduction of erythropoietin.- Intracellular signaling by the erythropoietin receptor.- Mechanism of erythropoietin receptor activation.- Clinical utility.- Pharmacokinetics of erythropoiesis-stimulating agents.- Use of erythropoietic stimulating agents in the setting of renal disease.- Abuse of recombinant erythropoietins and blood products by athletes.- Role and regulation of iron metabolism in erythropoiesis and disease.- Nonhematopoietic effects of erythropoiesis-stimulating agents.
