From Radiobiology to Radiation Oncology

This book offers a wide perspective on the fundamental and state-of-the-art knowledge in radiobiology, radiation oncology, and the connection between both fields. Chapters incorporate basic concepts of cancer biology and radiobiology with advances in radiotherapy in cancer treatment for various types of cancer. Chapters review one or more areas of radiation oncology with topics ranging from the application of radiotherapy in various cancers, the use of advanced techniques such as FLASH radiotherapy, applications of artificial intelligence in treatment planning, and more importantly, the current and potential strategies to reduce the toxic effects of radiation. This book incorporates interdisciplinary concepts by exploring recent approaches like radiogenomics for personalizing radiotherapy and the effects of the microbiome on radiation research.
Teaching the basics of radiobiology and connections between the theory and the practical aspects of radiotherapy techniques, this book is a useful reference for cancer researchers, practitioners, interdisciplinary researchers in related fields, and students in radiation oncology and radiobiology. Through this integration of strong scientific foundations and clinical applicability, this book provides future research directions and rationales for readers looking to expand their knowledge about radiation with the most recent and essential data on the subject.

Sommario

1. Overview on Cancer Biology and cancer hallmarks.- 2. Introduction to Seven R s of Radiobiology.- 3. Radiosensitivity and its contributing biologic factors.- 4. Innovative Strategies to Enhance Radiosensitivity: Hyperthermia, Nanoparticles, and DNA Repair Inhibition.- 5. Role of Tumor-Initiating Stem Cells in Tumor Resistance and Relapse.-  6. Cancer Cell s Fates upon Radiation.- 7. Overview of Radiotherapy Techniques and Modalities: Conventional and Modern Approaches.-  8. Recent Advances in Radiotherapy of Breast cancer.-  Chapter 9 Advances in Radiotherapy of Gastrointestinal Cancers.-  10. Recent Advances in Radiotherapy of Lung Cancer.-  11. Advances in Radiotherapy of Genitourinary Cancers.-  12. Advances in Radiotherapy of Brain Tumors.-  13.  Advances in Head and Neck Cancer.- 14. Application of radiotherapy in oligometastatic disease.-  15. Emerging Role of FLASH Radiotherapy.- 16. Novel Approaches to Counteract Radiotherapy Toxicities: Focusing on Radioprotectors and Radiation Mitigators.- 17. Advances in Radiotherapy using Artificial Intelligence.- 18. Radiogenomics: A Potential Approach for Personalized radiotherapy. 19. The Emerging role of Microbiome in Radiation Research.- 20. Future Directions in Radiobiology and Clinical Radiation Oncology.

Info autore

Dr. Farzad Taghizadeh-Hesary, M.D.
, is an assistant professor of radiation oncology at the Iran University of Medical Sciences. His research and clinical expertise lie at the intersection of radiation oncology, radiobiology, and cancer metabolism. Dr. Taghizadeh-Hesary's work focuses on integrating the tumor microenvironment and mitochondrial metabolism into cancer research and personalized radiotherapy. He has published over 90 peer-reviewed articles in high-impact journals and serves on


the editorial boards of leading oncology journals. Dr. Taghizadeh-Hesary has received numerous awards, including the prestigious Razi Medical Science ResearchPrize. With a deep understanding of the complex interplay between radiation, tumor biology, and metabolic pathways, Dr. Taghizadeh-Hesary’s work aims to develop innovative strategies for improving cancer treatment outcomes and enhancing the patients’ quality of life.

Sumel Ashique
is an assistant professor at the Department of Pharmaceutical Technology, Bharat Technology, West Bengal 711316, India. He has 5 years of teaching experience and has published 80+ papers in internationally and nationally accredited journals, including research, reviews, column articles, and an editorial in Scopus and Web of Science (WOS). He has knowledge in drug delivery, nanotechnology, and targeted treatment strategy. He holds five patents from IP and Australia and has authored 20 book chapters published by Bentham, Springer, Elsevier, and Taylor & Francis. Currently, he is editing 14 books under CRC Press, Elsevier, Taylor and Francis, Wiley, Nova Science, and Springer. Also, he is now serving as a guest editor in the JoVE journal (IF 1.2, Scopus, and WOS), Current Probiotics (Bentham Science), and Current Indian Science Journal. He is a potential reviewer


in Elsevier, Springer, Taylor & Francis, Dove Press, Bentham, and Wiley journals due to his expertise in the field of targeted drug delivery, nanotechnology, gutmicrobiome, and postbiotics. Currently, he is pursuing his PhD degree from Lovely Professional University, Punjab, India (NAAC A++) in the pharmaceutical science department.

Dr. Neeraj Mishra
is working as Professor and Head, Department of Pharmaceutics in Amity Institute of Pharmacy, Gwalior since July 2019. He has around twenty years of teaching and research experience. He has more than 140 publications of International and National repute in recent concepts of novel drug delivery systems, localized drug delivery, targeted and controlled drug delivery of nanocarriers/ microparticles for the treatment of breast, colon cancer, and neurodegenerative disorders. Dr. Mishra has supervised 30 M Pharm and 2 PhD students. Dr. Mishra more than 4200 citations with h- index 36. The total cumulative Impact Factor of his published papers is more than 500 (as per SCOPUS). He has also written 25 Books and 45 book chapters in Elsevier, Bentham, Springer and Wiley publications, etc. He has also been granted 3 international patents and 2 Indian patents. Dr. Mishra is


recipient of “Distinguished Professor Award” 2019 from DST-NSTMIS, SPAICS, Indore, and M.P. in September 2019. Dr. Mishra has also received the “Outstanding Scientist Award” 2020, 6th International Scientist Awards on Engineering, Science, and Medicine, 20–21 June 2020, Chennai, India. Dr. Mishra has received the “Distinguished Professor Award” 2021 from Indian Pharmaceutical Association, MP State Branch, Indore. Dr Mishra has received the Best Academician Award in the Indian Pharmacy Graduate Association, M.P. State International Conference held on 06th May 2023 at DAVV Auditorium, Indore, India. Recently, honored to be in World Top 2% Scientists by prestigious Stanford University, CA, USA and Elsevier in 2025. Honored to be in the Stanford University Scientists Rankings conducted by AD Scientific Index - World Scientists rankings in 2024, 2022 and 2025.

Dr. Babak Behnam (MD, PhD)
, is an academic researcher in the field of medical molecular biology and translational medicine at the American University and professor


at the Floret Genomic Center. He earned his M.D. from Iran University of Medical Sciences (IUMS) in 1997 before specializing in genomic medicine, completing an M.Sc. in molecular medicine at the University of Sheffield and a Ph.D. in human genetics at the University College London (UCL) in 2005. After his Ph.D., Dr. Behnam moved to the USA, where he was awarded an NIH-based Ruth L. Kirschstein NRSA fellowship and completed four years of postdoctoral training at the University of Michigan and the University of Central Florida. His research focuses on molecular metastatic pathways, cancer biology, and mitochondrial genetics. At IUMS, he served as associate professor of human genetics, established and directed the medical genetics laboratory at OB/GYN and Children’s University Hospitals for seven years, and taught and mentored numerous students. Upon returning to the USA, Dr. Behnam joined the NIH Undiagnosed Disease Program while completing an ABMGG-accredited clinical biochemical genetics fellowship at NHGRI, NIH. He later transitioned to Regulatory Affairs at NSF International, overseeing FDA submissions and compliance. As Co-Founder and Chief Scientific Officer (CSO) of Avicenna Biotech Research, he leads IP strategy and serves as a Medical Science Liaison (MSL). A prolific academic, Dr. Behnam has authored over 80 peer-reviewed publications, contributed to several chapters of five books, and holds editorial roles at MDPI Cancers and Frontiers. He also holds multiple patents in addiction therapies and cancer therapeutics.

Riassunto

This book offers a wide perspective on the fundamental and state-of-the-art knowledge in radiobiology, radiation oncology, and the connection between both fields. Chapters incorporate basic concepts of cancer biology and radiobiology with advances in radiotherapy in cancer treatment for various types of cancer. Chapters review one or more areas of radiation oncology with topics ranging from the application of radiotherapy in various cancers, the use of advanced techniques such as FLASH radiotherapy, applications of artificial intelligence in treatment planning, and more importantly, the current and potential strategies to reduce the toxic effects of radiation. This book incorporates interdisciplinary concepts by exploring recent approaches like radiogenomics for personalizing radiotherapy and the effects of the microbiome on radiation research.
Teaching the basics of radiobiology and connections between the theory and the practical aspects of radiotherapy techniques, this book is a useful reference for cancer researchers, practitioners, interdisciplinary researchers in related fields, and students in radiation oncology and radiobiology. Through this integration of strong scientific foundations and clinical applicability, this book provides future research directions and rationales for readers looking to expand their knowledge about radiation with the most recent and essential data on the subject.

Dettagli sul prodotto

• Con la collaborazione di: Sumel Ashique (Editore), Babak Behnam (Editore), Neeraj Mishra (Editore), Neeraj Mishra et al (Editore), Farzad Taghizadeh-Hesary (Editore)
• Editore: Springer, Berlin
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 31.08.2025
• EAN: 9783031957239
• ISBN: 978-3-0-3195723-9
• Pagine: 405
• Illustrazioni: XI, 405 p. 15 illus., 13 illus. in color.
• Categorie: Scienze naturali, medicina, informatica, tecnica > Medicina > Branche non cliniche; Genetik (nicht-medizinisch), Medizinische Bildverarbeitung: Radiologie, Artificial Intelligence (AI), Radiotherapy, Microbiome, Cancer Biology, Radiation Oncology, Cancer Genetics and Genomics, Radiobiology, radiation biology, Radiogenomics, Radio-immunotherapy