Ulteriori informazioni
Strategies for repositioning and forming eutectic mixtures by binary combination of Active Principle/Coformer or Active Principle/Active Principle are widely used to combat multi-resistant bacteria and increase solubility, bioavailability and consequently therapeutic effect. The choice of coformer is based on its chemical structure and the presence of proton-donating and proton-accepting functional groups capable of establishing non-covalent intermolecular interactions, such as hydrogen bonding, Van Der Waals forces and pi-pi interactions. The active ingredient chosen for repositioning is Celecoxib. The coformers are salicylic acid (A.SAL), maleic acid (A.MAL), nicotinamide (NIC), succinic acid (A.SUC) and cinnamic acid (A.CIN).
Info autore
Doktor ALLAL Farida, prepodawatel' i nauchnyj sotrudnik Uniwersiteta Amar Telidli, Laguat, Alzhir. Oblast' moih interesow - termodinamika i ee primenenie k binarnym i mnogokomponentnym smesqm, a takzhe ocenka mezhmolekulqrnyh wzaimodejstwij w binarnyh kombinaciqh aktiwnyh ingredientow.
