Ulteriori informazioni
Sommario
Zn2+ Modulation of Neurotransmitter Transporters.- Molecular Microfluorometry: Converting Arbitrary Fluorescence Units into Absolute Molecular Concentrations to Study Binding Kinetics and Stoichiometry in Transporters.- Structure/Function Relationships in Serotonin Transporter: New Insights from the Structure of a Bacterial Transporter.- The Importance of Company: Na+ and Cl? Influence Substrate Interaction with SLC6 Transporters and Other Proteins.- Currents in Neurotransmitter Transporters.- Mutational Analysis of Glutamate Transporters.- The Diverse Roles of Vesicular Glutamate Transporter 3.- Extraneuronal Monoamine Transporter and Organic Cation Transporters 1 and 2: A Review of Transport Efficiency.- The Role of SNARE Proteins in Trafficking and Function of Neurotransmitter Transporters.- Regulation of the Dopamine Transporter by Phosphorylation.- The Dopamine Transporter: A Vigilant Border Control for Psychostimulant Action.- Oligomerization of Neurotransmitter Transporters: A Ticket from the Endoplasmic Reticulum to the Plasma Membrane.- Acute Regulation of Sodium-Dependent Glutamate Transporters: A Focus on Constitutive and Regulated Trafficking.- Regulation and Dysregulation of Glutamate Transporters.- Regulation of Vesicular Monoamine and Glutamate Transporters by Vesicle-Associated Trimeric G Proteins: New Jobs for Long-Known Signal Transduction Molecules.- Human Genetics and Pharmacology of Neurotransmitter Transporters.- ADHD and the Dopamine Transporter: Are There Reasons to Pay Attention?.- Inactivation of 5HT Transport in Mice: Modeling Altered 5HT Homeostasis Implicated in Emotional Dysfunction, Affective Disorders, and Somatic Syndromes.- Lessons from the Knocked-Out Glycine Transporters.- The Norepinephrine Transporter in Physiology and Disease.-The High-Affinity Choline Transporter: A Critical Protein for Sustaining Cholinergic Signaling as Revealed in Studies of Genetically Altered Mice.
Riassunto
This book is a representative survey of the current status of the structure, function, regulation and molecular pharmacology of Neurotransmitter Transporters. It provides an overview of insights generated in the past five years. The volume serves as a useful compendium of current concepts and an inspiring starting point. It is a source for students interested in this emerging field as well as for experienced scientists looking for an update.
