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For more than 25 years clinicians and scientists have been trying to improve the treatment of acute hepatic failure. Several devices were developed and hemodialysis procedures were refined. The treatment of fulminant hepatic failure and end-stage liver cirrhosis by liver transplantation became a standard procedure. However, for the successful management of critical situations before and after liver surgery, artificial liver support is still needed.
This book is the proceedings of the Falk Symposium No. 145 on Artificial Liver Support , held on 27--28 January 2005 in Ulm, Germany, and provides an overview of the possibilities and limitations of the existing procedures and devices available for artificial liver support.
The results achieved with albumin dialysis (MARS System), the Prometheus System, and dialysis and hemofiltration or plasma exchange as well as modular extracorporeal liver support (MELS) and the Amsterdam bioartificial liver are discussed in detail regarding their effects in different clinical situations.
In the second half of the book, the remaining problems and expectations for the future of clinical hepatocyte transplantation and stem cell therapy are elucidated.
Leading experts in the fields of artificial devices, bioartificial devices, hepatocyte transplantation and stem cells present the latest data on these topics. Their experience and their data are summarized in this volume, thus providing an exceptional overview of the problems and future perspectives in the field of artificial liver support.
Sommario
Title of principal contributors. Title of chairpersons. Preface.
Introduction. Acute hepatic failure - when do we need liver support?
Section I: Artificial Devices: 1 Overview on artificial liver support in patients with acute liver failure. 2 Experience with albumin dialysis MARS in liver failure. 3 Special device: Prometheus system. 4 Dialysis, haemofiltration and plasma exchange in acute liver failure.
Section II: Bioartificial Devices: 5 Modular extracorporeal liver support (MELS). 6 The Amsterdam bioartificial liver. 7 Perspectives and future of artificial and bioartificial devices.
Section III: Hepatocyte Transplantation: 8 Latest experimental models in hepatocyte transplantation. 9 Human hepatocyte transplantation.
Section IV: Stem Cells: 10 Liver stem cells. 11 Stem cell regeneration in human liver. Index.
