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"A useful handbook to guide laboratory staff in mastering the techniques of flow cytometry in diagnosing complex hematological malignancies. Practical and current, it presents comprehensive information, from instrument settings and panel construction to data interpretation. Will support users in recognizing relevant immunophenotypic abnormalities"--
Sommario
1. Flow cytometry in clinical haematopathology: basic principles and data analysis of multiparameter data sets Francis Lacombe and Marie-Christine Béné; 2. Antigens Marie-Christine Béné and Anna Porwit; 3. Flow cytometry of normal blood, bone marrow and lymphatic tissue Anna Porwit and Marie-Christine Béné; 4. Reactive conditions and other diseases where flow cytometric findings may mimic haematological malignancies Marie-Christine Béné, Wolfgang Kern and Anna Porwit; 5. Examples of immunophenotypic features in various categories of acute leukaemia Marie-Christine Béné and Anna Porwit; 6. Acute lymphoid leukaemia (all) and minimal/measurable residual disease in all Barbara Buldini, Elena Varotto and Andrea Zangrando; 7. Immunophenotyping of mature b-cell lymphomas Olof Axler and Anna Porwit; 8. Plasma cell myeloma and related disorders Anna Porwit and Marie Christine Béné; 9. Mature t-cell neoplasms and natural killer-cell malignancies Anne Tierens; 10. Flow cytometric diagnosis of classic hodgkin lymphoma in lymph nodes Lori Soma and Jonathan R. Fromm; 11. Measurable residual disease in acute myeloid leukaemia Jacqueline Cloos, Angèle Kelder, Dave de Leeuw and Costa Bachas; 12. Ambiguous lineage and mixed phenotype acute leukaemia Anna Porwit and Marie-Christine Béné; 13. Flow cytometry in myelodysplastic syndromes Theresia M. Westers and Arjan A. van de Loosdrecht; 14. Future applications of flow cytometry and related techniques Marie Christine Béné, Anna Porwit and Francis Lacombe.
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Anna Porwit MD PhD is Professor Emerita at the Division of Pathology, Lund University, Sweden. She has also held professor positions at the Karolinska Institute, Stockholm, Sweden, and at the University of Toronto, ON, Canada. She is a co-author of over 200 original papers and has contributed to the 'WHO Classification of Haematopoietic Malignancies' (2008 and 2016).Marie Christine Béné is Professor Emerita of Hematology, former Professor of Immunology, and lastly head of the Hematology Biology Department in Nantes University Hospital. She has been largely involved in flow cytometry applications in diagnosis and follow-up. She has co-authored over 500 publications, has contributed to the 'WHO Classification of Haematopoietic Malignancies' (2008 and 2016) and leads the European LeukemiaNet WP10 on morphology and flow cytometry.
