AID for Immunoglobulin Diversity

Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Sommario

Discovery of Activation-Induced Cytidine Deaminase, the Engraver of Antibody Memory
DNA Deamination in Immunity: Aid in the Context of Its Apobec Relatives
The Role of Activation Induced Deaminase in Antibody Diversification and Chromosome Translocations
Targeting of AID-mediated Sequence Diversification by cis-acting Determinants
AID-initiated Purposeful Mutations in Immunoglobulin Genes
Post-translational AID Regulation
Beyond SHM and CSR: AID and Related Cytidine Deaminases in the Host Response to Viral Infection
AID expression and tumorigenesis
Pathophysiology of B Cell Intrinsic Immunoglobulin Class Switch Recombination Deficiencies

Dettagli sul prodotto

• Con la collaborazione di: Frederick W. Alt (Editore), Alt Frederick W. (Editore), Tasuku Honjo (Editore)
• Editore: Elsevier Science & Technology
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 21.06.2007
• EAN: 9780123737069
• ISBN: 978-0-12-373706-9
• Dimensioni: 152 mm x 19 mm x 229 mm
• Peso: 664 g
• Serie: Advances in Immunology
• Categorie: Scienze naturali, medicina, informatica, tecnica > Medicina > Branche cliniche; Immunology, MEDICAL / Immunology