Inhibitors of the Ras Superfamily G-proteins, Part B

Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins.

Sommario

1. Discovery of Small-Molecule Ras Inhibitors that Display Anti-Tumor Activity by Interfering with Ras.GTP-Effector InteractionFumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto and Tohru Kataoka
2. An Orthosteric Inhibitor of the RAS-SOS InteractionSeth Nickerson, Stephen T. Joy, Paramjit S. Arora and Dafna Bar-Sagi
3. Conformation-Specific Inhibitors of Raf kinasesXiaolun Wang and Kristin Schleicher
4. Inhibitors of the ERK Mitogen-activated Protein Kinase Cascade for Targeting RAS Mutant CancersLeanna Gentry, Ahmed A. Samatar and Channing J. Der
5. Inhibiting the RAS - PI3K Pathway in Cancer TherapyClare Sheridan and Julian Downward
6. The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras CancersJonathan M. Cooper, Brian O. Bodemann and Michael A. White
7. p21-Activated Kinase InhibitorsJoachim Rudolph, James J. Crawford, Klaus P. Hoeflich, and Jonathan Chernoff
8. Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Towards Inhibiting K-Ras and N-Ras Functions Fuyuhiko Tamanoi and Jie Lu
9. Synthetic Lethal Genetic Screens in Ras Mutant CancersBing Yu and Ji Luo

Dettagli sul prodotto

• Con la collaborazione di: Channing J. Der (Editore), Fuyuhiko Tamanoi (Editore)
• Editore: Elsevier Science & Technology
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 12.12.2013
• EAN: 9780124201460
• ISBN: 978-0-12-420146-0
• Dimensioni: 152 mm x 16 mm x 229 mm
• Peso: 570 g
• Serie: The Enzymes
• Categorie: Scienze naturali, medicina, informatica, tecnica > Biologia > Tematiche generali, enciclopedie; SCIENCE / Life Sciences / Biochemistry, Xenobiotics