Peripheral T-Cell Lymphomas

THE PERIPHERAL T-CELL LYMPHOMAS
 
Provides a comprehensive look at Peripheral T-Cell lymphomas, including the group's unique geographic distribution, underlying genetics, and novel treatments
 
Peripheral T-Cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represent 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat.
 
For the first time in a single volume, The Peripheral T-Cell Lymphomas presents a comprehensive survey of this complex and rare group of blood cancers. Featuring contributions from an international team of leading authorities in the various aspects of PTCL, this authoritative text covers biology, epidemiology, classification, approved and emerging drugs, molecular genetics, and more. Detailed clinical chapters address diagnosis, prognosis, and treatment of each of the major PTCL subtypes identified in the 2018 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This much-needed resource:
* Covers the biological basis, epidemiology, classification, and treatment of PTCL
* Discusses the future of the field, including global collaboration efforts and novel approaches to PCTL
* Explores the role of biologics in PTCL and autologous and allogeneic stem-cell transplantation
* Offers new insights on molecular pathogenesis, innovative therapeutics, and novel drug combinations
* Features contributions from the Chairs The T-Cell Lymphoma Forum: the world's largest meeting focused on PTCL
 
Reflecting the unique epidemiology and genetic diversity of the PTCL, The Peripheral T-Cell Lymphomas is an indispensable source of data, insight, and references for the medical community, particularly oncologists and hematologists in both training and practice.

Sommario

Contributors xix
 
About the Companion Website xxiii
 
Part I Biological Basis of the Peripheral T-cell Lymphomas 1
 
1 The Fundamentals of T-cell Lymphocyte Biology 3
Claudio Tripodo and Stefano A. Pileri
 
Introduction 3
 
General View of the Differentiation and Function of T Lymphocytes 3
 
The T-cell System as a Frame for Peripheral T-cell Lymphoma: Taking Plasticity into Account 5
 
Must Reads 7
 
References 7
 
2 Mechanisms of T-cell Lymphomagenesis 9
François Lemonnier, Philippe Gaulard and Laurence de Leval
 
Introduction 9
 
Oncogenic Events in the Transformation of T or Natural Killer Cells 9
 
Genetic Lesions 9
 
Deregulated Pathways in Peripheral T-cell Lymphoma Oncogenesis (Figure 2.1, Table 2.1) 10
 
Signaling Pathways 13
 
Cell-cycle Control 14
 
Immune Surveillance 14
 
Role of the Microenvironment in Peripheral T-cell Lymphoma 15
 
The Model of Angio-immunoblastic T-cell Lymphoma and T Follicular Helper-derived Peripheral T-cell Lymphoma 15
 
Specific Microenvironment Components Present in Other Primary Cutaneous T-cell Lymphoma Entities 16
 
Underlying Factors Favoring the Tumor Transformation 18
 
Viruses 18
 
Chronic Antigenic Stimulation 19
 
Other Factors 19
 
Cell of Origin (Table 2.1) 20
 
Conclusion 22
 
Must Reads 22
 
References 22
 
3 Epigenetics of T-cell Lymphoma 27
H. Miles Prince, Jasmine Zain, Anas Younes, Sean Whittaker, Owen A. O'Connor and Sean Harrop
 
Introduction 27
 
Epigenetic Pathways Altered in T-cell Lymphoma 27
 
Epigenetic Changes Within Specific T-cell Lymphoma Subtypes 31
 
Peripheral T-cell Lymphoma Not Otherwise Specified 32
 
Angioimmunoblastic T-cell Lymphoma and Peripheral T-cell Lymphoma with T Follicular Helper Phenotype 32
 
Anaplastic Large-cell Lymphoma 33
 
Adult T-cell Leukemia/Lymphoma 33
 
Intestinal T-cell Lymphoma 34
 
Hepatosplenic T-cell Lymphomas 34
 
Extranodal Natural Killer/T-cell Lymphoma 34
 
Mycosis Fungoides and Sézary Syndrome 35
 
Established and Emerging Drugs Targeting the T-cell Lymphoma Epigenome 35
 
DNA Methyltransferase Inhibitors 35
 
Isocitrate Dehydrogenase Inhibitors 36
 
EZH2 Inhibitors 37
 
BET Inhibitors 38
 
Protein Arginine Methyltransferases Inhibitors 38
 
Combination Therapies Involving Epigenetic Targeting Agents 38
 
Future Directions 38
 
Must Reads 39
 
References 39
 
4 Animal Models of T-cell Lymphoma 47
Keiichiro Hattori, Raksha Shrestha, Tatsuhiro Sakamoto, Manabu Kusakabe and Mamiko Sakata-Yanagimoto
 
Introduction 47
 
Angioimmunoblastic T-cell Lymphoma 50
 
The ROQUIN Mouse Model 50
 
The Mouse Models Recapitulating Human Angioimmunoblastic T-cell Lymphoma Genomic Features 50
 
Tet2 Gene Trap Mice 50
 
G17V RHOA Mouse Model 50
 
PDX Models of Angioimmunoblastic T-cell Lymphoma 51
 
Anaplastic Large T-cell Lymphoma 51
 
Viral and Chimeric Models 51
 
Transgenic Models 51
 
CRISPR-Based Models 52
 
PDX Models of Anaplastic Large-Cell Lymphomas 52
 
Human T-cell Lymphotropic Virus Type 1 Adult T-cell Leukemia/Lymphoma 52
 
Mice Expressing HTLV-1 Viral Proteins 52
 
PDX Models of Adult T-cell Leukemia/Lymphoma 52
 
Cutaneous T-cell Lymphoma 53
 
Enteropathy-associated T-cell Lymphoma 53
 
Conclusion 53
 
Must Reads 53
 
References 54
 
Part II Epide

Info autore

About the Editors
Owen A. O'Connor, American Cancer Society Research Professor, Professor of Medicine, Department of Medicine, Division of Hematology and Oncology, Program for T-cell Lymphoma Research, Department of Microbiology, Immunology, and Cancer Research, University of Virginia Cancer Center, Charlottesville, VA, USA. Won Seog Kim, MD, PhD is Professor of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Pier Luigi Zinzani, MD, PhD is Professor of Hematology, Director of Lymphoma and CLL Unit, and Chief of Phase I clinical trials, Institute of Hematology, University of Bologna, Italy.

Dettagli sul prodotto

• Autori: Won Seog Kim, Owen A O'Connor, Owen A. Kim O''''connor, Pier L Zinzani
• Con la collaborazione di: Won Seog Kim (Editore), Pier L Zinzani (Editore), Owen A. O'Connor (Editore), O'Connor Owen A. (Editore), Won Seog Kim (Editore), Pier L. Zinzani (Editore)
• Editore: Wiley, John and Sons Ltd
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 11.05.2021
• EAN: 9781119671312
• ISBN: 978-1-119-67131-2
• Pagine: 416
• Categorie: Scienze naturali, medicina, informatica, tecnica > Medicina > Tematiche generali; Hämatologie, Medizin, Molekularbiologie, Life Sciences, Biowissenschaften, Hematology, molecular biology, Medical Science, Medizinische Onkologie, Medical Oncology