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With contributions from leading authorities, this volume reviews over a century of aspirin research and use. The most authoritative reference currently available, it provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin. The book includes the commercial use of aspirin and outlines the chemical properties and synthesis of aspirin and its derivatives developed over the last 100 years. Physicians, pharmacists, pharmacologists, toxicologists, and chemists will find this definitive reference an invaluable insight into this popular and fascinating drug.
Sommario
History and Development of the Salicylates. The Industrial History of Analgesics: The Evolution of Analgesics and Antipyretics. Occurrence, Properties and Synthetic Developments of the Salicylates. Pharmacokinetics and Metabolism of the Salicylates. Metabolism and Pharmacokinetics of Ibuprofen. Pharmacokinetics and Metabolism of Paracetamol (Acetaminophen). Pharmacology and Biochemistry of Salicylates and Related Drugs. Side-effects and Toxicology of the Salicylates. Reye's Syndrome and Aspirin. Salicylates in the Treatment of Acute Pain. Acetysalicylic Acid for the Prevention and Treatment of Thromboembolic Diseases. Use of Salicylates in Rheumatic and Related Conditions. Aspirin and NSAIDs in the Prevention of Cancer, Alzheimer's Disease and other Novel Therapeutic Actions.
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Kim D. Rainsford
