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Informationen zum Autor Anthony S. Lubiniecki Klappentext Presents an interdisciplinary approach! integrating biochemistry! biology! genetics! and engineering for the effective production of protein pharmaceuticals. This title offers a biological perspective of large-scale animal cell culture. It examines diverse processing strategies and process management. Zusammenfassung An interdisciplinary approach, integrating biochemistry, biology, genetics, and engineering for the effective production of protein pharmaceuticals. The volume offers a biological perspective of large-scale animal cell culture and examines diverse processing strategies, process management, regulator Inhaltsverzeichnis Series Introduction, Series Introduction, Contributors, 1: Large-Scale Mammalian Cell Culture: A Perspective, 2: Use of Recombinant DNA Technology for Engineering Mammalian Cells to Produce Proteins, 3: Large-Scale Animal Cell Culture: A Biological Perspective, 4: Mammalian Cell Physiology, 5: Cell Banking, 6: Expression of Cloned Proteins in Mammalian Cells: Regulation of Cell-Associated Parameters, 7: Assay Requirements for Cell Culture Process Development, 8: Nonperfused Attachment Systems for Cell Cultivation, 9: Perfusion Systems for Cell Cultivation, 10: Suspension Culture of Mammalian Cells, 11: Microcarrier Culture Systems, 12: Microencapsulation of Mammalian Cells, 13: Continuous Culture with Macroporous Matrix, Fluidized Bed Systems, 14: Downstream Processing of Proteins from Mammalian Cells, 15: Management of Process Technology, 16: Monitoring and Control of Animal Cell Bioreactors: Biochemical Engineering Considerations, 17: Methods for the Detection of Adventitious Viruses in Cell Cultures Used in the Production of Biotechnology Products, 18: Continuous Cell Substrate Considerations, 19: Process Validation for Cell Culture-Derived Pharmaceutical Proteins, 20: Quality Control of rDNA-Derived Human Tissue-Type Plasminogen Activator, 21: Design and Construction of Manufacturing Facilities for Mammalian Cell-Derived Pharmaceuticals, 22: Large-Scale Propagation of Insect Cells, Index...
